Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.46 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | F2 | P00734 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | F10 | P00742 | 2/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1097246 | 0.80 | USP30 (0.43) | CHRNB2CHRNA4USP30POLBNPC1 | |
| SCHEMBL1097248 | 0.80 | USP30 (0.43) | CHRNB2CHRNA4USP30POLBNPC1 | |
| SCHEMBL1096377 | 0.76 | USP30 (0.41) | CHRNB2CHRNA4USP30NPC1RAB9A | |
| SCHEMBL1096379 | 0.76 | USP30 (0.41) | CHRNB2CHRNA4USP30NPC1RAB9A | |
| SCHEMBL1096532 | 0.73 | POLB (0.40) | CHRNB2CHRNA4USP30POLBLMNA | |
| SCHEMBL1096810 | 0.73 | POLB (0.39) | CHRNB2CHRNA4USP30POLBLMNA | |
| SCHEMBL1097250 | 0.72 | USP30 (0.42) | CHRNB2CHRNA4USP30NPC1RAB9A | |
| SCHEMBL1096609 | 0.72 | USP30 (0.40) | CHRNB2CHRNA4USP30POLBLMNA | |
| SCHEMBL4947837 | 0.71 | F10 (0.32) | F2LMNAF10SMN1; SMN2HDAC2 | |
| SCHEMBL1096239 | 0.71 | POLB (0.38) | CHRNB2CHRNA4USP30POLBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893572-A2 | FACTOR XA INHIBITORS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2008-03-05 | — | — | EP | disclosed |
| WO-2006002099-A2 | FACTOR XA INHIBITORS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2006-01-05 | — | — | WO | disclosed |