Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.60 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3977220 | 0.94 | HTT (0.65) | HTTSMN1; SMN2GAAKMT2AMEN1 | |
| Propyne SCHEMBL4947242 | 0.86 | SMN1; SMN2 (0.48) | HTTSMN1; SMN2GAAKMT2AMEN1 | |
| SCHEMBL27715447 | 0.85 | HTT (0.56) | HTTSMN1; SMN2GAAKMT2AMEN1 | |
| SCHEMBL3975278 | 0.85 | HTT (0.55) | HTTSMN1; SMN2GAAKMT2AMEN1 | |
| SCHEMBL4948655 | 0.84 | HTT (0.58) | HTTSMN1; SMN2GAAKMT2AMEN1 | |
| SCHEMBL3980271 | 0.84 | HTT (0.70) | HTTSMN1; SMN2GAAKMT2AMEN1 | |
| SCHEMBL3978785 | 0.84 | SMN1; SMN2 (0.54) | HTTSMN1; SMN2GAAKMT2AMEN1 | |
| SCHEMBL3973666 | 0.84 | HTT (0.54) | HTTSMN1; SMN2GAAKMT2AMEN1 | |
| SCHEMBL3976793 | 0.84 | HTT (0.54) | HTTSMN1; SMN2GAAKMT2AMEN1 | |
| SCHEMBL3975091 | 0.83 | HTT (0.54) | HTTSMN1; SMN2GAAKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1931661-B1 | ISOXAZOLO DERIVATIVES AS GABA A ALPHA5 INVERSE AGONISTS | HOFFMANN LA ROCHE (CH) | 2008-11-19 | — | — | EP | disclosed |