Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4947254 | 0.88 | HTT (0.45) | HTTSMN1; SMN2POLBALOX15TSHR | |
| SCHEMBL3982594 | 0.85 | SMN1; SMN2 (0.63) | HTTSMN1; SMN2POLBALOX15TSHR | |
| Propyne SCHEMBL4948649 | 0.84 | HTT (0.60) | HTTSMN1; SMN2POLBALOX15TSHR | |
| SCHEMBL3980271 | 0.84 | HTT (0.70) | HTTSMN1; SMN2POLBTSHRLMNA | |
| SCHEMBL14546677 | 0.83 | HTT (0.61) | HTTSMN1; SMN2POLBALOX15TSHR | |
| SCHEMBL3977220 | 0.83 | HTT (0.65) | HTTSMN1; SMN2POLBALOX15TSHR | |
| SCHEMBL3981169 | 0.82 | HTT (0.56) | HTTSMN1; SMN2POLBALOX15TSHR | |
| SCHEMBL3980161 | 0.78 | HTT (0.60) | HTTSMN1; SMN2POLBALOX15TSHR | |
| SCHEMBL3977188 | 0.78 | SMN1; SMN2 (0.55) | HTTSMN1; SMN2POLBTSHRLMNA | |
| SCHEMBL3983004 | 0.78 | HTT (0.65) | HTTSMN1; SMN2POLBALOX15TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1931661-B1 | ISOXAZOLO DERIVATIVES AS GABA A ALPHA5 INVERSE AGONISTS | HOFFMANN LA ROCHE (CH) | 2008-11-19 | — | — | EP | disclosed |