Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.48 |
| ▸ | ACHE | P22303 | 2/20 | 0.44 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.43 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | HRH2 | P25021 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cyclopentane SCHEMBL4948650 | 1.00 | HRH4 (0.48) | HRH4ACHEPTPN11KDM4EHRH3 | |
| Cyclohexane SCHEMBL4949527 | 1.00 | HRH4 (0.48) | HRH4ACHEPTPN11KDM4EHRH3 | |
| SCHEMBL4183373 | 0.85 | HRH4 (0.48) | HRH4KDM4EHRH3NR3C2MEN1 | |
| SCHEMBL4190163 | 0.83 | NPC1 (0.47) | HRH4KDM4EHRH3NR3C2MEN1 | |
| SCHEMBL4187232 | 0.82 | HRH4 (0.46) | HRH4ACHEHRH3NR3C2TMEM97 | |
| SCHEMBL4172566 | 0.82 | HTR1F (0.54) | HRH4NR3C2ALDH1A1HTR1ANPC1 | |
| SCHEMBL4179669 | 0.82 | HRH4 (0.46) | HRH4ACHEHRH3NR3C2MEN1 | |
| SCHEMBL4190178 | 0.80 | SMN1; SMN2 (0.47) | HRH4PTPN11KDM4EHRH3MEN1 | |
| SCHEMBL5611101 | 0.80 | KMT2A (0.49) | ACHEKDM4EHRH3KMT2AALDH1A1 | |
| SCHEMBL4175682 | 0.80 | MAPK1 (0.49) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828134-B1 | PIPERAZINYL PYRIDINE DERIVATIVES AS ANTI-OBESITY AGENTS | HOFFMANN LA ROCHE (CH) | 2008-10-29 | — | — | EP | claimed |