Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 8/20 | 0.69 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | CSF1R | P07333 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8311654 | 0.90 | PDE4B (0.66) | PDE4BMTNR1BCSF1R | |
| SCHEMBL4949101 | 0.89 | PDE4B (0.68) | PDE4BMTNR1BCSF1R | |
| Hydrochloric Acid SCHEMBL2480331 | 0.89 | PDE4B (0.65) | PDE4BMTNR1BCSF1R | |
| SCHEMBL4949456 | 0.89 | PDE4B (0.67) | PDE4BMTNR1BCSF1R | |
| SCHEMBL4950089 | 0.89 | PDE4B (0.67) | PDE4BMTNR1BJAK2JAK1TYK2 | |
| SCHEMBL4948178 | 0.88 | PDE4B (0.61) | PDE4BMTNR1B | |
| SCHEMBL4951313 | 0.87 | PDE4B (0.65) | PDE4BMTNR1BCSF1R | |
| SCHEMBL4628806 | 0.86 | PDE4B (0.57) | PDE4BMTNR1BCSF1R | |
| SCHEMBL4626847 | 0.85 | PDE4B (0.56) | PDE4BMTNR1BCSF1R | |
| SCHEMBL4627674 | 0.85 | PDE4B (0.56) | PDE4BMTNR1BJAK2JAK3CSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633748-B1 | QUINOLINE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | GLAXO GROUP LTD (GB) | 2008-03-05 | — | — | EP | claimed |