Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 10/20 | 0.42 |
| ▸ | CSF1R | P07333 | 10/20 | 0.41 |
| ▸ | PDE4A | P27815 | 2/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4947634 | 0.92 | CSF1R (0.45) | PDE4BCSF1RPDE4APDE4CPDE4D | |
| SCHEMBL4949242 | 0.89 | PDE4B (0.48) | PDE4BCSF1RPDE4APDE4CPDE4D | |
| SCHEMBL4950378 | 0.88 | PDE4B (0.42) | PDE4BCSF1RPDE4APDE4CPDE4D | |
| SCHEMBL4950086 | 0.88 | PDE4B (0.42) | PDE4BCSF1RPDE4APDE4CPDE4D | |
| SCHEMBL4949887 | 0.85 | PDE4B (0.55) | PDE4BCSF1R | |
| SCHEMBL2478942 | 0.85 | PDE4B (0.52) | PDE4BCSF1R | |
| SCHEMBL4952205 | 0.84 | PDE4B (0.43) | PDE4BCSF1RPDE4APDE4CPDE4D | |
| SCHEMBL2476991 | 0.84 | PDE4B (0.46) | PDE4BCSF1RPDE4APDE4CPDE4D | |
| SCHEMBL4951019 | 0.80 | PDE4B (0.46) | PDE4BCSF1R | |
| SCHEMBL4951706 | 0.80 | CSF1R (0.45) | PDE4BCSF1RPDE4APDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633748-B1 | QUINOLINE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | GLAXO GROUP LTD (GB) | 2008-03-05 | — | — | EP | claimed |