Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 8/20 | 0.42 |
| ▸ | CSF1R | P07333 | 9/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4947745 | 0.92 | CSF1R (0.45) | PDE4BCSF1RPDE4APDE4CPDE4D | |
| SCHEMBL4949242 | 0.90 | PDE4B (0.48) | PDE4BCSF1RPDE4APDE4CPDE4D | |
| SCHEMBL4944364 | 0.89 | PDE4B (0.43) | PDE4BCSF1RTHRB | |
| SCHEMBL4950378 | 0.89 | PDE4B (0.42) | PDE4BCSF1RPDE4APDE4CPDE4D | |
| SCHEMBL4949692 | 0.88 | PDE4B (0.42) | PDE4BCSF1RPDE4APDE4CPDE4D | |
| SCHEMBL4944904 | 0.86 | CSF1R (0.43) | PDE4BCSF1RPDE4APDE4CPDE4D | |
| SCHEMBL2509132 | 0.85 | PDE4B (0.53) | PDE4BCSF1RTHRBTP53 | |
| SCHEMBL1275855 | 0.83 | PDE4B (0.47) | PDE4BCSF1R | |
| SCHEMBL4951019 | 0.81 | PDE4B (0.46) | PDE4BCSF1R | |
| SCHEMBL4951706 | 0.80 | CSF1R (0.45) | PDE4BCSF1RPDE4APDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633748-B1 | QUINOLINE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | GLAXO GROUP LTD (GB) | 2008-03-05 | — | — | EP | claimed |