Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.66 |
| ▸ | ELOVL1 | Q9BW60 | 2/20 | 0.60 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.56 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.56 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.56 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.56 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.56 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.56 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.56 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.56 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.56 |
| ▸ | MRE11 | P49959 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | PRKACA | P17612 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21225987 | 1.00 | HDAC6 (0.66) | HDAC6ELOVL1HDAC3HDAC4HDAC1 | |
| SCHEMBL21225986 | 1.00 | HDAC6 (0.66) | HDAC6ELOVL1HDAC3HDAC4HDAC1 | |
| SCHEMBL4950607 | 0.94 | HDAC6 (0.68) | HDAC6ELOVL1HDAC3HDAC4HDAC1 | |
| SCHEMBL21224492 | 0.87 | HDAC6 (0.67) | HDAC6ELOVL1HDAC3HDAC4HDAC1 | |
| SCHEMBL21224494 | 0.87 | HDAC6 (0.67) | HDAC6ELOVL1HDAC3HDAC4HDAC1 | |
| SCHEMBL1244330 | 0.86 | HDAC6 (0.59) | HDAC6ELOVL1HDAC3HDAC4HDAC1 | |
| SCHEMBL21224196 | 0.86 | HDAC6 (0.66) | HDAC6ELOVL1HDAC1ROCK1ROCK2 | |
| SCHEMBL21224198 | 0.86 | HDAC6 (0.66) | HDAC6ELOVL1HDAC1ROCK1ROCK2 | |
| SCHEMBL21241893 | 0.85 | HDAC6 (0.64) | HDAC6ELOVL1HDAC3HDAC4HDAC1 | |
| SCHEMBL21241891 | 0.85 | HDAC6 (0.64) | HDAC6ELOVL1HDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080076741-A1 | ENHANCEMENT OF TIGECYCLINE POTENCY USING EFFLUX PUMP INHIBITORS | REMPEX PHARMACEUTICALS, INC. | 2008-03-27 | — | — | US | disclosed |
| US-20060003944-A1 | Bacterial efflux pump inhibitors and methods of treating bacterial infections | REMPEX PHARMACEUTICALS, INC. | 2006-01-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080076741-A1 | ENHANCEMENT OF TIGECYCLINE POTENCY USING EFFLUX PUMP INHIBITORS | ABCB1, ABCB11, SLC47A2 | HDAC6 262/4885ELOVL1 86/4885HDAC3 812/4885 |
| US-20060003944-A1 | Bacterial efflux pump inhibitors and methods of treating bacterial infections | ABCB11, ABCB1, ABCC1 | HDAC6 509/4885ELOVL1 369/4885HDAC3 985/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.