Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 13/20 | 0.50 |
| ▸ | SYK | P43405 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 4/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4952284 | 0.94 | PDE4B (0.45) | PDE4BSYKCSF1RTHRB | |
| SCHEMBL4948205 | 0.91 | PDE4B (0.55) | PDE4BSYKCSF1RPDE4APDE4C | |
| SCHEMBL4946564 | 0.90 | PDE4B (0.49) | PDE4BSYKCSF1RLRRK2 | |
| SCHEMBL4951698 | 0.89 | PDE4B (0.46) | PDE4BSYKCSF1RLRRK2 | |
| SCHEMBL1275327 | 0.88 | PDE4B (0.66) | PDE4BSYKCSF1R | |
| SCHEMBL2481386 | 0.83 | PDE4B (0.59) | PDE4BSYKCSF1RTHRB | |
| SCHEMBL4627471 | 0.83 | PDE4B (0.47) | PDE4BSYKCSF1R | |
| SCHEMBL1276112 | 0.82 | PDE4B (0.70) | PDE4B | |
| SCHEMBL1275591 | 0.80 | PDE4B (0.63) | PDE4BSYKCSF1RLRRK2 | |
| SCHEMBL4946547 | 0.80 | PDE4B (0.77) | PDE4BPDE4APDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633748-B1 | QUINOLINE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | GLAXO GROUP LTD (GB) | 2008-03-05 | — | — | EP | claimed |