Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 15/20 | 0.55 |
| ▸ | CSF1R | P07333 | 3/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4952284 | 0.93 | PDE4B (0.45) | PDE4BCSF1RSYK | |
| SCHEMBL4950488 | 0.91 | PDE4B (0.50) | PDE4BCSF1RPDE4APDE4CPDE4D | |
| SCHEMBL2479181 | 0.88 | PDE4B (0.71) | PDE4BCSF1R | |
| SCHEMBL4951698 | 0.86 | PDE4B (0.46) | PDE4BCSF1RSYK | |
| SCHEMBL4944841 | 0.84 | PDE4B (0.77) | PDE4BCSF1RPDE4APDE4CPDE4D | |
| SCHEMBL2481386 | 0.82 | PDE4B (0.59) | PDE4BCSF1RSYK | |
| SCHEMBL4946407 | 0.82 | PDE4B (0.66) | PDE4BCSF1R | |
| SCHEMBL4949236 | 0.82 | PDE4B (0.66) | PDE4BCSF1R | |
| SCHEMBL4952552 | 0.81 | PDE4B (0.65) | PDE4BCSF1RTP53 | |
| SCHEMBL4946564 | 0.81 | PDE4B (0.49) | PDE4BCSF1RSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633748-B1 | QUINOLINE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | GLAXO GROUP LTD (GB) | 2008-03-05 | — | — | EP | claimed |