Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.38 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | TTR | P02766 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.34 |
| ▸ | ACLY | P53396 | 1/20 | 0.33 |
| ▸ | KDM5A | P29375 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CA4 | P22748 | 1/20 | 0.33 |
| ▸ | CA6 | P23280 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4950027 | 0.92 | TDP1 (0.39) | KDM4EPTGS1GRIA4PTGS2TDP1 | |
| SCHEMBL4950718 | 0.90 | RARB (0.41) | KDM4EPTGS1GRIA4PTGS2TDP1 | |
| SCHEMBL4950475 | 0.89 | SRD5A2 (0.46) | KDM4EPTGS1GRIA4TDP1TTR | |
| SCHEMBL4945608 | 0.88 | TDP1 (0.43) | KDM4EPTGS1PTGS2TDP1NPSR1 | |
| SCHEMBL4953693 | 0.87 | GRIA4 (0.49) | KDM4EPTGS1GRIA4PTGS2SRD5A2 | |
| SCHEMBL4949007 | 0.86 | GRM5 (0.36) | KDM4EPTGS1GRIA4TDP1 | |
| SCHEMBL4952509 | 0.86 | TDP1 (0.37) | KDM4EPTGS1GRIA4PTGS2TDP1 | |
| SCHEMBL252191 | 0.85 | TSHR (0.42) | PTGS1GRIA4TDP1EGFRTTR | |
| SCHEMBL27703688 | 0.84 | TTR (0.41) | KDM4EGRIA4PTGS2TDP1TTR | |
| SCHEMBL4952472 | 0.84 | F11 (0.35) | KDM4EPTGS1GRIA4PTGS2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893597-B1 | AMPA RECEPTOR POTENTIATORS | LILLY CO ELI (US) | 2008-11-12 | — | — | EP | disclosed |