Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 11/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 9/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.42 |
| ▸ | S1PR5 | Q9H228 | 4/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.42 |
| ▸ | GPR55 | Q9Y2T6 | 4/20 | 0.41 |
| ▸ | CNR2 | P34972 | 3/20 | 0.41 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7175052 | 0.99 | OPRD1 (0.47) | OPRD1KCNH2OPRK1S1PR5S1PR1 | |
| SCHEMBL4281185 | 0.90 | OPRD1 (0.46) | OPRD1KCNH2OPRK1GPR55CNR2 | |
| Hydrochloric Acid SCHEMBL4276817 | 0.88 | OPRD1 (0.61) | OPRD1KCNH2OPRK1CYP2D6 | |
| Hydrochloric Acid SCHEMBL4269370 | 0.87 | OPRD1 (0.49) | OPRD1KCNH2OPRK1CYP2D6 | |
| Hydrochloric Acid SCHEMBL4284815 | 0.85 | OPRD1 (0.47) | OPRD1KCNH2OPRK1CYP2D6 | |
| SCHEMBL4273935 | 0.84 | OPRD1 (0.54) | OPRD1KCNH2OPRK1CNR2CYP2D6 | |
| Hydrochloric Acid SCHEMBL4276512 | 0.84 | OPRD1 (0.46) | OPRD1KCNH2OPRK1S1PR5S1PR1 | |
| Hydrochloric Acid SCHEMBL4284761 | 0.83 | OPRD1 (0.46) | OPRD1KCNH2OPRK1CYP2D6 | |
| Hydrochloric Acid SCHEMBL4270071 | 0.81 | OPRD1 (0.55) | OPRD1KCNH2OPRK1CYP2D6 | |
| Hydrochloric Acid SCHEMBL4272464 | 0.80 | OPRD1 (0.52) | OPRD1KCNH2OPRK1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1232160-B1 | SPIRO(2H-1-BENZOPYRAN-2,4'-PIPERIDINE)DERIVATES AS GLYCINE TRANSPORT INHIBITORS | ORGANON NV (NL) | 2008-06-18 | — | — | EP | disclosed |