Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 20/20 | 0.64 |
| ▸ | GABRB3 | P28472 | 20/20 | 0.64 |
| ▸ | GABRA5 | P31644 | 20/20 | 0.64 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.48 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.48 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3570212 | 0.90 | GABRG2 (0.79) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL4883052 | 0.88 | GABRG2 (0.77) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL4950821 | 0.87 | GABRG2 (0.71) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL4948122 | 0.85 | GABRG2 (0.79) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL4946797 | 0.85 | GABRG2 (0.48) | GABRG2GABRB3GABRA5 | |
| SCHEMBL4892858 | 0.84 | GABRG2 (0.60) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL4948747 | 0.83 | GABRG2 (0.61) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL4892071 | 0.82 | GABRG2 (0.57) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL3884039 | 0.81 | GABRG2 (0.76) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL3871120 | 0.80 | GABRG2 (0.77) | GABRG2GABRB3GABRA5GABRA1GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1809297-B1 | IMIDAZO[1,5A]TRIAZOLO[1,5D]BENZODIAZEPINE DERIVATIVES FOR THE TREATMENT OF COGNITIVE DISORDERS | HOFFMANN LA ROCHE (CH) | 2008-07-30 | — | — | EP | claimed |