Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | APAF1 | O14727 | 1/20 | 0.37 |
| ▸ | GRK2 | P25098 | 1/20 | 0.37 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 4/20 | 0.35 |
| ▸ | RAB9A | P51151 | 4/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4950993 | 0.81 | HDAC6 (0.41) | POLBMAPTHDAC6MIFITGB3 | |
| SCHEMBL3984476 | 0.81 | POLB (0.45) | POLBMAPTHDAC6APAF1GRK2 | |
| SCHEMBL2674041 | 0.72 | POLB (0.53) | POLBAPAF1GRK2APOBEC3GPDE4A | |
| SCHEMBL3986282 | 0.70 | MAPT (0.43) | POLBMAPTHDAC6PDE4APDE4B | |
| SCHEMBL3986317 | 0.70 | POLB (0.54) | POLBAPAF1GRK2APOBEC3GPDE4A | |
| SCHEMBL3985968 | 0.69 | HDAC6 (0.46) | POLBMAPTHDAC6PDE4APDE4B | |
| SCHEMBL3984077 | 0.68 | CA1 (0.50) | PDE4APDE4BPDE4CPDE4DATM | |
| SCHEMBL3985973 | 0.67 | POLB (0.39) | POLBMAPTHDAC6APAF1GRK2 | |
| SCHEMBL24831446 | 0.66 | POLB (0.55) | POLBMAPTAPAF1GRK2APOBEC3G | |
| SCHEMBL3986367 | 0.65 | MIF (0.48) | POLBMAPTAPAF1GRK2APOBEC3G |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893572-A2 | FACTOR XA INHIBITORS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2008-03-05 | — | — | EP | disclosed |
| WO-2006002099-A2 | FACTOR XA INHIBITORS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2006-01-05 | — | — | WO | disclosed |