Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 12/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12068237 | 0.79 | PDE10A (0.54) | PDE10ALMNAMAPTKDM4ECYP3A4 | |
| SCHEMBL83775 | 0.78 | PDE10A (0.48) | PDE10ALMNAMAPTKDM4ECYP3A4 | |
| SCHEMBL605923 | 0.78 | PDE10A (0.50) | PDE10ALMNAMAPTKDM4ECYP3A4 | |
| SCHEMBL10309409 | 0.77 | PDE10A (0.59) | PDE10ALMNAMAPTKDM4ECYP3A4 | |
| Ammonia Solution, Strong SCHEMBL17583545 | 0.77 | PDE10A (0.49) | PDE10ALMNAMAPTKDM4ECYP3A4 | |
| SCHEMBL10345238 | 0.77 | PDE10A (0.72) | PDE10ALMNAMAPTKDM4ETLR7 | |
| SCHEMBL15033539 | 0.75 | PDE10A (0.48) | PDE10ALMNAMAPTKDM4ECYP3A4 | |
| Bromide SCHEMBL13822734 | 0.75 | PDE10A (0.48) | PDE10ALMNAMAPTKDM4ECYP3A4 | |
| SCHEMBL10277184 | 0.74 | PDE10A (0.50) | PDE10ALMNAMAPTKDM4ECYP3A4 | |
| SCHEMBL17237846 | 0.73 | PDE10A (0.66) | PDE10ALMNAMAPTKDM4ECYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1578910-A4 | NITRILASES | VERENIUM CORP (US) | 2008-06-04 | — | — | EP | disclosed |
| EP-1578910-A2 | NITRILASES | DIVERSA CORPORATION (US) | 2005-09-28 | — | — | EP | disclosed |
| WO-2003000840-A2 | NITRILASES | DIVERSA CORPORATION (US) | 2003-01-03 | — | — | WO | disclosed |