Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR5 | P35346 | 15/20 | 0.59 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4955177 | 0.92 | SSTR5 (0.70) | SSTR5HRH1HTR2BLTA4H | |
| SCHEMBL4952469 | 0.91 | SSTR5 (0.61) | SSTR5HRH1HTR2BLTA4H | |
| SCHEMBL4955761 | 0.84 | SSTR5 (0.69) | SSTR5HRH1HTR2BACHE | |
| SCHEMBL3583834 | 0.83 | SSTR5 (0.83) | SSTR5HRH1HTR2BACHE | |
| SCHEMBL4958304 | 0.83 | SSTR5 (0.57) | SSTR5HRH1HTR2BLTA4H | |
| SCHEMBL4955151 | 0.83 | SSTR5 (0.49) | SSTR5LTA4HBCHEACHEKDM4E | |
| SCHEMBL4958519 | 0.80 | SSTR5 (0.54) | SSTR5LTA4H | |
| SCHEMBL4954437 | 0.76 | SSTR5 (0.48) | SSTR5LTA4HNPSR1KDM4EALDH1A1 | |
| SCHEMBL4955178 | 0.76 | SSTR5 (0.81) | SSTR5HRH1HTR2B | |
| SCHEMBL4952476 | 0.75 | SSTR5 (0.72) | SSTR5HRH1HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1858901-B1 | BENZOTHIAZOLE, THIAZOLOPYRIDINE, BENZOOXAZOLE AND OXAZOLOPYRIDINE DERIVATIVES AS ANTIDIABETIC COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2008-11-05 | — | — | EP | disclosed |