Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 3/20 | 0.58 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.58 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.58 |
| ▸ | PTGDR2 | Q9Y5Y4 | 8/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4960185 | 0.93 | PTGDR2 (0.63) | AKR1B1AKR1B10AKR1A1PTGDR2 | |
| SCHEMBL4961382 | 0.92 | PTGDR2 (0.54) | AKR1B1AKR1B10AKR1A1PTGDR2 | |
| SCHEMBL4960118 | 0.90 | PTGDR2 (0.64) | AKR1B1AKR1B10AKR1A1PTGDR2 | |
| SCHEMBL4961366 | 0.89 | PTGDR2 (0.61) | AKR1B1PTGDR2 | |
| SCHEMBL4958399 | 0.86 | AKR1B1 (0.51) | AKR1B1PTGDR2 | |
| SCHEMBL4962605 | 0.84 | PTGDR2 (0.62) | AKR1B1PTGDR2 | |
| SCHEMBL4962400 | 0.84 | PTGDR2 (0.53) | AKR1B1PTGDR2 | |
| SCHEMBL4961232 | 0.83 | PTGDR2 (0.63) | AKR1B1PTGDR2 | |
| SCHEMBL10974094 | 0.80 | PTGDR2 (0.61) | AKR1B1PTGDR2 | |
| SCHEMBL4960642 | 0.80 | PTGDR2 (0.60) | AKR1B1PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1891075-A1 | TRICYCLIC SPIRO DERIVATIVES AS CRTH2 MODULATORS | LABORATOIRES SERONO S.A. (CH) | 2008-02-27 | — | — | EP | disclosed |
| WO-2006125784-A1 | TRICYCLIC SPIRO DERIVATIVES AS CRTH2 MODULATORS | LABORATOIRES SERONO S.A. (CH) | 2006-11-30 | — | — | WO | disclosed |