Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALCRL | Q16602 | 17/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1274913 | 0.88 | CALCRL (0.46) | CALCRLCA9MAP2K2 | |
| SCHEMBL1394328 | 0.88 | CALCRL (0.46) | CALCRLCA9MAP2K2 | |
| SCHEMBL378986 | 0.88 | CALCRL (0.46) | CALCRLCA9MAP2K2 | |
| SCHEMBL15935913 | 0.84 | CALCRL (0.44) | CALCRLMAP2K2 | |
| SCHEMBL1714985 | 0.84 | BRD4 (0.42) | CALCRL | |
| SCHEMBL13015183 | 0.81 | CALCRL (0.39) | CALCRLMAP2K2 | |
| SCHEMBL1715431 | 0.80 | ALDH1A1 (0.44) | CALCRLKDM4EKMT2ATDP1MAP2K2 | |
| SCHEMBL12152864 | 0.80 | CALCRL (0.43) | CALCRLMAP2K2 | |
| SCHEMBL12655216 | 0.80 | CALCRL (0.41) | CALCRLMAP2K2 | |
| SCHEMBL16181909 | 0.77 | NR1H2 (0.37) | CALCRLCA9KDM4EGAAAPEX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1606264-B1 | MONOCYCLIC ANILIDE SPIROHYDANTOIN CGRP RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME (US) | 2012-05-02 | — | — | EP | disclosed |
| US-8071771-B2 | Bicyclic spirohydantoin CGRP receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2011-12-06 | — | — | US | disclosed |
| US-8071770-B2 | Spirohydantoin aryl CGRP receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2011-12-06 | — | — | US | disclosed |
| US-8071770-B2 | Spirohydantoin aryl CGRP receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2011-12-06 | — | — | US | disclosed |
| EP-1794146-B1 | TRICYCLIC ANILIDE SPIROHYDANTOIN CGRP RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME (US) | 2011-08-03 | — | — | EP | disclosed |
| US-7968540-B2 | Spirohydantoin tricyclic CGRP receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2011-06-28 | — | — | US | disclosed |
| US-7968540-B2 | Spirohydantoin tricyclic CGRP receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2011-06-28 | — | — | US | disclosed |
| EP-1606286-B1 | BENODIAZEPINE SPIROHYDANTOIN CGRP RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME (US) | 2011-05-11 | — | — | EP | disclosed |
| EP-1951251-B1 | SPIROHYDANTOIN ARYL CGRP RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME (US) | 2010-12-29 | — | — | EP | disclosed |
| US-7750010-B2 | Tricyclic anilide spirohydantion CGRP receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2010-07-06 | — | — | US | disclosed |
| WO-2007061695-A2 | BICYCLIC SPIROHYDANTOIN CGRP RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2007-05-31 | — | — | WO | disclosed |
| WO-2007061694-A2 | SPIROHYDANTOIN TRICYCLIC CGRP RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2007-05-31 | — | — | WO | disclosed |
| US-7205293-B2 | Benodiazepine spirohydantoin CGRP receptor antagonists | MERCK & CO., INC. (US) | 2007-04-17 | — | — | US | disclosed |
| US-7205293-B2 | Benodiazepine spirohydantoin CGRP receptor antagonists | MERCK & CO., INC. (US) | 2007-04-17 | — | — | US | disclosed |
| US-7202251-B2 | Bicyclic anilide spirohydantoin CGRP receptor antagonists | MERCK & CO., INC. (US) | 2007-04-10 | — | — | US | disclosed |
| US-7202251-B2 | Bicyclic anilide spirohydantoin CGRP receptor antagonists | MERCK & CO., INC. (US) | 2007-04-10 | — | — | US | disclosed |
| US-7192954-B2 | Monocyclic anilide spirohydantoin CGRP receptor antagonists | MERCK & CO., INC. (US) | 2007-03-20 | — | — | US | disclosed |
| US-7192954-B2 | Monocyclic anilide spirohydantoin CGRP receptor antagonists | MERCK & CO., INC. (US) | 2007-03-20 | — | — | US | disclosed |
| US-7189722-B2 | Aryl spirohydantoin CGRP receptor antagonists | MERCK & CO., INC. (US) | 2007-03-13 | — | — | US | disclosed |
| US-7189722-B2 | Aryl spirohydantoin CGRP receptor antagonists | MERCK & CO., INC. (US) | 2007-03-13 | — | — | US | disclosed |