Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.71 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.57 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.53 |
| ▸ | HTR7 | P34969 | 5/20 | 0.52 |
| ▸ | PDE4A | P27815 | 1/20 | 0.52 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.52 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4959496 | 0.90 | LMNA (0.73) | LMNAMAPK1ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL4957364 | 0.89 | LMNA (0.71) | LMNAMAPK1ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL4957819 | 0.88 | LMNA (0.71) | LMNAMAPK1ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL14115519 | 0.88 | LMNA (0.70) | LMNAMAPK1ALDH1A1CYP1A2CYP3A4 | |
| Hydrochloric Acid SCHEMBL4955827 | 0.87 | LMNA (0.69) | LMNAMAPK1ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL4957089 | 0.83 | LMNA (1.00) | LMNAMAPK1ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL4958242 | 0.82 | LMNA (0.80) | LMNAMAPK1ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL4958923 | 0.82 | LMNA (0.80) | LMNAMAPK1ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL4958462 | 0.82 | LMNA (0.80) | LMNAMAPK1ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL4958937 | 0.82 | LMNA (0.80) | LMNAMAPK1ALDH1A1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008094909-A2 | QUINAZOLINONE AND FUSED PYRIMIDINONE COMPOUNDS AND THEIR USE IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | XENON PHARMACEUTICALS INC. (CA) | 2008-08-07 | — | — | WO | disclosed |
| WO-2008094909-A2 | QUINAZOLINONE AND FUSED PYRIMIDINONE COMPOUNDS AND THEIR USE IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | XENON PHARMACEUTICALS INC. (CA) | 2008-08-07 | — | — | WO | disclosed |