Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | FASN | P49327 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4207946 | 1.00 | PKM (0.39) | PKMTSHRALDH1A1KDM4EKMT2A | |
| SCHEMBL3414025 | 0.91 | TSHR (0.42) | PKMTSHRALDH1A1KDM4EKMT2A | |
| SCHEMBL4204812 | 0.85 | PKM (0.43) | PKMTSHRALDH1A1KDM4EKMT2A | |
| SCHEMBL4210764 | 0.85 | TSHR (0.36) | PKMTSHRALDH1A1KDM4EKMT2A | |
| SCHEMBL2977046 | 0.82 | TSHR (0.40) | PKMTSHRALDH1A1KDM4EKMT2A | |
| SCHEMBL2981293 | 0.82 | TSHR (0.40) | PKMTSHRALDH1A1KDM4EKMT2A | |
| SCHEMBL1021584 | 0.82 | TSHR (0.40) | PKMTSHRALDH1A1KDM4EKMT2A | |
| SCHEMBL4725094 | 0.82 | TSHR (0.40) | PKMTSHRALDH1A1KDM4EKMT2A | |
| SCHEMBL2977050 | 0.82 | TSHR (0.40) | PKMTSHRALDH1A1KDM4EKMT2A | |
| SCHEMBL1021583 | 0.82 | TSHR (0.40) | PKMTSHRALDH1A1KDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1871772-A1 | QUINOLINONE COMPOUNDS AS 5-HT4 RECEPTOR AGONISTS | Theravance, Inc. (US) | 2008-01-02 | — | — | EP | claimed |
| WO-2006094063-A1 | QUINOLINONE COMPOUNDS AS 5-HT4 RECEPTOR AGONISTS | THERAVANCE, INC. (US) | 2006-09-08 | — | — | WO | claimed |