Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.80 |
| ▸ | LMNA | P02545 | 2/20 | 0.80 |
| ▸ | MEN1 | O00255 | 2/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.67 |
| ▸ | BLM | P54132 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.61 |
| ▸ | PDE10A | Q9Y233 | 6/20 | 0.59 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.56 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.56 |
| ▸ | PDE4A | P27815 | 1/20 | 0.55 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.55 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.55 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.55 |
| ▸ | GFER | P55789 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4956845 | 0.91 | LMNA (0.77) | MAPK1LMNAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL4957089 | 0.89 | LMNA (1.00) | MAPK1LMNAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL4958333 | 0.89 | LMNA (0.73) | MAPK1LMNAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL4957073 | 0.86 | LMNA (0.77) | MAPK1LMNAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL4958242 | 0.85 | LMNA (0.80) | MAPK1LMNAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL4958937 | 0.85 | LMNA (0.80) | MAPK1LMNAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL4958462 | 0.85 | LMNA (0.80) | MAPK1LMNAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL4958923 | 0.85 | LMNA (0.80) | MAPK1LMNAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL4955782 | 0.84 | LMNA (0.73) | MAPK1LMNAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL4955785 | 0.84 | LMNA (0.73) | MAPK1LMNAMEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008094909-A2 | QUINAZOLINONE AND FUSED PYRIMIDINONE COMPOUNDS AND THEIR USE IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | XENON PHARMACEUTICALS INC. (CA) | 2008-08-07 | — | — | WO | claimed |
| WO-2008094909-A2 | QUINAZOLINONE AND FUSED PYRIMIDINONE COMPOUNDS AND THEIR USE IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | XENON PHARMACEUTICALS INC. (CA) | 2008-08-07 | — | — | WO | disclosed |