SCHEMBL4959314

SCHEMBL4959314

NC(=O)OCC(c1ccc(F)c(F)c1)n1ncnn1

nearest known ligand 0.37

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
SLC6A2 P23975 4/20 0.37
SLC6A4 P31645 4/20 0.37
SLC6A3 Q01959 4/20 0.37
CYP19A1 P11511 2/20 0.36
CYP17A1 P05093 3/20 0.34
CYP2C9 P11712 3/20 0.34
CYP2C19 P33261 3/20 0.34
CYP1A2 P05177 2/20 0.34
CYP2D6 P10635 1/20 0.34
PKM P14618 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
NPSR1 Q6W5P4 1/20 0.34
CES2 O00748 1/20 0.33
CES1 P23141 1/20 0.33
CCR9 P51686 1/20 0.31
RPS6KB1 P23443 1/20 0.31
AKT1 P31749 1/20 0.31
AURKB Q96GD4 1/20 0.31
INCENP Q9NQS7 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4962287 0.86 CYP17A1 (0.36) SLC6A2SLC6A4SLC6A3CYP19A1CYP17A1
SCHEMBL4958071 0.84 CYP19A1 (0.51) SLC6A2SLC6A4SLC6A3CYP19A1CYP17A1
SCHEMBL4957281 0.83 SLC6A3 (0.56) SLC6A2SLC6A4SLC6A3CYP19A1CYP17A1
SCHEMBL4957523 0.83 CYP1A2 (0.37) SLC6A2SLC6A4SLC6A3CYP19A1CYP17A1
SCHEMBL4958049 0.82 SLC6A2 (0.57) SLC6A2SLC6A4SLC6A3CYP17A1CYP2C9
SCHEMBL4959372 0.82 TNF (0.46) SLC6A2SLC6A4SLC6A3CYP17A1CYP2C9
SCHEMBL4960122 0.82 SLC6A2 (0.39) SLC6A2SLC6A4SLC6A3CYP19A1CYP1A2
SCHEMBL4957486 0.81 CYP1A2 (0.51) SLC6A2SLC6A4SLC6A3CYP19A1CYP2C19
SCHEMBL4961016 0.81 CYP17A1 (0.36) SLC6A2SLC6A4SLC6A3CYP19A1CYP17A1
SCHEMBL4958201 0.81 CYP1A2 (0.38) SLC6A2SLC6A4SLC6A3CYP1A2CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1879873-A1 NEUROTHERAPEUTIC AZOLE COMPOUNDS SK Holdings Co., Ltd. (KR) 2008-01-23 EP disclosed
WO-2006112685-A1 NEUROTHERAPEUTIC AZOLE COMPOUNDS SK HOLDINGS CO., LTD. (KR) 2006-10-26 WO disclosed