Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 5/20 | 0.34 |
| ▸ | RORC | P51449 | 4/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.30 |
| ▸ | CRHBP | P24387 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 2/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2926312 | 1.00 | REN (0.34) | RENRORCMEN1KMT2AMAPT | |
| SCHEMBL2922570 | 1.00 | REN (0.34) | RENRORCMEN1KMT2AMAPT | |
| SCHEMBL2922568 | 1.00 | REN (0.34) | RENRORCMEN1KMT2AMAPT | |
| SCHEMBL3465765 | 0.94 | REN (0.35) | RENRORCMEN1KMT2AMAPT | |
| SCHEMBL3465766 | 0.94 | REN (0.35) | RENRORCMEN1KMT2AMAPT | |
| SCHEMBL13435408 | 0.94 | REN (0.35) | RENRORCMEN1KMT2AMAPT | |
| SCHEMBL13435410 | 0.92 | REN (0.35) | RENRORC | |
| SCHEMBL2926597 | 0.92 | REN (0.35) | RENRORC | |
| SCHEMBL2923802 | 0.92 | REN (0.35) | RENRORC | |
| SCHEMBL2923804 | 0.92 | REN (0.35) | RENRORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1897879-A2 | 2,4,5 substituted piperidines as renin inhibitors | Speedel Experimenta AG (CH) | 2008-03-12 | — | — | EP | disclosed |