Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | HRH3 | Q9Y5N1 | 13/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4957557 | 0.92 | LMNA (0.56) | LMNAMAPK1HRH3MEN1KMT2A | |
| SCHEMBL14115057 | 0.90 | LMNA (0.55) | LMNAMAPK1HRH3MEN1KMT2A | |
| SCHEMBL4956972 | 0.82 | LMNA (0.60) | LMNAMAPK1HRH3MEN1KMT2A | |
| SCHEMBL14115201 | 0.81 | LMNA (0.60) | LMNAMAPK1HRH3MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL4958631 | 0.80 | LMNA (0.59) | LMNAMAPK1HRH3MEN1KMT2A | |
| SCHEMBL4957819 | 0.80 | LMNA (0.71) | LMNAMAPK1HRH3MEN1KMT2A | |
| SCHEMBL4956966 | 0.79 | LMNA (0.58) | LMNAMAPK1HRH3MEN1KMT2A | |
| SCHEMBL4958473 | 0.79 | LMNA (0.58) | LMNAMAPK1HRH3MEN1KMT2A | |
| SCHEMBL4960314 | 0.78 | LMNA (0.64) | LMNAMAPK1HRH3MEN1KMT2A | |
| SCHEMBL4957798 | 0.78 | MEN1 (0.86) | LMNAMAPK1HRH3MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008094909-A2 | QUINAZOLINONE AND FUSED PYRIMIDINONE COMPOUNDS AND THEIR USE IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | XENON PHARMACEUTICALS INC. (CA) | 2008-08-07 | — | — | WO | claimed |
| WO-2008094909-A2 | QUINAZOLINONE AND FUSED PYRIMIDINONE COMPOUNDS AND THEIR USE IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | XENON PHARMACEUTICALS INC. (CA) | 2008-08-07 | — | — | WO | disclosed |