Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | TP53 | P04637 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | BLM | P54132 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.54 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4955792 | 0.93 | MEN1 (0.69) | MAPK1LMNATP53MEN1KMT2A | |
| SCHEMBL4957073 | 0.92 | LMNA (0.77) | MAPK1LMNATP53MEN1KMT2A | |
| SCHEMBL4467032 | 0.87 | MAPK1 (0.76) | MAPK1LMNAMEN1KMT2ABLM | |
| SCHEMBL8242227 | 0.86 | NPC1 (0.70) | MAPK1LMNAMEN1KMT2ABLM | |
| SCHEMBL4956958 | 0.84 | LMNA (0.72) | MAPK1LMNATP53MEN1KMT2A | |
| SCHEMBL4957618 | 0.83 | MAPK1 (0.60) | MAPK1LMNAMEN1KMT2ABLM | |
| SCHEMBL1484129 | 0.83 | MEN1 (0.66) | MAPK1LMNAMEN1KMT2ABLM | |
| SCHEMBL8649618 | 0.82 | MAPK1 (0.67) | MAPK1LMNAMEN1KMT2ABLM | |
| SCHEMBL4955797 | 0.82 | LMNA (0.72) | MAPK1LMNAMEN1KMT2ABLM | |
| SCHEMBL14115046 | 0.80 | LMNA (0.66) | MAPK1LMNATP53MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008094909-A2 | QUINAZOLINONE AND FUSED PYRIMIDINONE COMPOUNDS AND THEIR USE IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | XENON PHARMACEUTICALS INC. (CA) | 2008-08-07 | — | — | WO | disclosed |