Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.59 |
| ▸ | NPC1 | O15118 | 4/20 | 0.55 |
| ▸ | RAB9A | P51151 | 4/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.54 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12529816 | 0.99 | ALDH1A1 (0.60) | ALDH1A1NPC1RAB9AKMT2AHSD17B10 | |
| SCHEMBL14625553 | 0.80 | NPC1 (0.46) | ALDH1A1NPC1RAB9AKMT2AOPRM1 | |
| SCHEMBL12722482 | 0.78 | NTRK1 (0.45) | ALDH1A1NPC1RAB9AKMT2ANTRK1 | |
| SCHEMBL12529297 | 0.77 | HDAC4 (0.43) | ALDH1A1NPC1RAB9AKMT2ANTRK1 | |
| SCHEMBL13211426 | 0.77 | KMT2A (0.51) | NPC1RAB9AKMT2ASMN1; SMN2KDM4E | |
| SCHEMBL16597337 | 0.77 | KMT2A (0.59) | ALDH1A1NPC1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL31098476 | 0.77 | NPC1 (0.53) | ALDH1A1NPC1RAB9AKMT2AHSD17B10 | |
| SCHEMBL12315033 | 0.76 | NPC1 (0.46) | ALDH1A1NPC1RAB9ANTRK1 | |
| SCHEMBL14507080 | 0.76 | NPC1 (0.58) | ALDH1A1NPC1RAB9AKMT2AHSD17B10 | |
| SCHEMBL12265892 | 0.75 | HDAC3 (0.43) | NPC1RAB9ANTRK1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904472-A1 | THIOPHENE COMPOUNDS AND THROMBOPOIETIN RECEPTOR ACTIVATORS | Nissan Chemical Industries, Ltd. (JP) | 2008-04-02 | — | — | EP | disclosed |
| WO-2007010954-A1 | THIOPHENE COMPOUNDS AND THROMBOPOIETIN RECEPTOR ACTIVATORS | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2007-01-25 | — | — | WO | disclosed |