Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK5 | Q9Y337 | 3/20 | 0.63 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.59 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.59 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.59 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.59 |
| ▸ | ACE | P12821 | 1/20 | 0.51 |
| ▸ | CMA1 | P23946 | 8/20 | 0.46 |
| ▸ | REN | P00797 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.45 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.45 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.45 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.45 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | TACR2 | P21452 | 1/20 | 0.45 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL496474 | 0.91 | KLK5 (0.61) | KLK5ADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL496475 | 0.91 | KLK5 (0.61) | KLK5ADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL496315 | 0.90 | KLK5 (0.60) | KLK5ADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL495900 | 0.90 | ADORA3 (0.64) | KLK5ADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL495899 | 0.90 | ADORA3 (0.64) | KLK5ADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL7269359 | 0.89 | ADORA3 (0.60) | KLK5ADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL7267808 | 0.87 | ADORA3 (0.62) | KLK5ADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL7390369 | 0.86 | KLK5 (0.52) | KLK5ADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL14948890 | 0.86 | CYP3A4 (0.60) | KLK5ADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL496157 | 0.86 | KLK5 (0.61) | KLK5ADORA3ADORA2AADORA2BADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910317-B1 | 1-AMINO LINKED COMPOUNDS | LILLY CO ELI (US) | 2013-07-03 | — | — | EP | disclosed |
| US-8106090-B2 | Antidiabetic agents; prevent of non-insulin dependent diabetes | ELI LILLY AND COMPANY (US) | 2012-01-31 | — | — | US | disclosed |
| US-20080207735-A1 | 1-Amino Linked Compounds | ELI LILLY AND COMPANY | 2008-08-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080207735-A1 | 1-Amino Linked Compounds | DPP4, DPP3, DPP9 | KLK5 3927/4885ADORA3 223/4885ADORA2A 1170/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.