Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 13/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | SGK1 | O00141 | 1/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | ULK1 | O75385 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | GRK2 | P25098 | 1/20 | 0.31 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.31 |
| ▸ | GRK3 | P35626 | 1/20 | 0.31 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.31 |
| ▸ | CLK2 | P49760 | 1/20 | 0.31 |
| ▸ | GSK3A | P49840 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4618895 | 0.80 | KLKB1 (0.37) | — | |
| SCHEMBL31355068 | 0.70 | GPR3 (0.41) | CYP2D6SLC6A2SLC6A4SLC6A3MAPK1 | |
| SCHEMBL4619802 | 0.70 | MAPK1 (0.35) | MAPK1SGK1ROCK2ULK1CDK2 | |
| SCHEMBL4600049 | 0.70 | GPR3 (0.41) | CYP2D6SLC6A2SLC6A4SLC6A3MAPK1 | |
| SCHEMBL27666697 | 0.70 | GPR3 (0.41) | CYP2D6SLC6A2SLC6A4SLC6A3KMT2A | |
| SCHEMBL3202976 | 0.69 | KMT2A (0.40) | CYP2D6SLC6A2SLC6A4SLC6A3KMT2A | |
| SCHEMBL31355071 | 0.69 | KMT2A (0.40) | CYP2D6SLC6A2SLC6A4SLC6A3KMT2A | |
| SCHEMBL27549930 | 0.68 | GPR3 (0.42) | CYP2D6SLC6A2SLC6A4SLC6A3KMT2A | |
| SCHEMBL28900959 | 0.68 | CYP2D6 (0.39) | CYP2D6SLC6A2SLC6A4SLC6A3MAPK1 | |
| SCHEMBL2868793 | 0.67 | CYP2D6 (0.44) | CYP2D6SLC6A2SLC6A4SLC6A3HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080207695-A1 | Thrombin Inhibiting 2-Oxo-1,2,5,6-Tetrahydropyridine Derivatives | ASTRAZENECA AB (SE) | 2008-08-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080207695-A1 | Thrombin Inhibiting 2-Oxo-1,2,5,6-Tetrahydropyridine Derivatives | F2R, F2, SERPINE1 | CYP2D6 215/4885SLC6A2 4476/4885SLC6A4 4372/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.