Efonidipine

Efonidipine

SCHEMBL49637

CC1=C(C(=O)OCCN(Cc2ccccc2)c2ccccc2)C(c2cccc([N+](=O)[O-])c2)C(P2(=O)OCC(C)(C)CO2)=C(C)N1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ABCB1 P08183 2/20 1.00
CACNA1C Q13936 10/20 0.59
CYP1A2 P05177 4/20 0.59
CYP3A4 P08684 4/20 0.59
CYP2D6 P10635 4/20 0.59
CYP2C9 P11712 4/20 0.59
CYP2C19 P33261 4/20 0.59
LMNA P02545 3/20 0.59
MAPT P10636 3/20 0.59
TDP1 Q9NUW8 3/20 0.59
TSHR P16473 3/20 0.59
ADORA3 P0DMS8 3/20 0.59
ADRA2A P08913 2/20 0.59
TBXA2R P21731 2/20 0.59
NPC1 O15118 1/20 0.59
ABCC4 O15439 1/20 0.59
ABCB11 O95342 1/20 0.59
PGR P06401 1/20 0.59
CHRM2 P08172 1/20 0.59
HTR1A P08908 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Efonidipine SCHEMBL29410289 1.00 ABCB1 (1.00) ABCB1CACNA1CCYP1A2CYP3A4CYP2D6
Efonidipine SCHEMBL29379054 1.00 ABCB1 (1.00) ABCB1CACNA1CCYP1A2CYP3A4CYP2D6
Efonidipine SCHEMBL49638 1.00 ABCB1 (1.00) ABCB1CACNA1CCYP1A2CYP3A4CYP2D6
Efonidipine SCHEMBL349046 0.99 ABCB1 (0.99) ABCB1CACNA1CCYP1A2CYP3A4CYP2D6
Efonidipine SCHEMBL332377 0.99 ABCB1 (0.99) ABCB1CACNA1CCYP1A2CYP3A4CYP2D6
Efonidipine SCHEMBL678571 0.99 ABCB1 (0.97) ABCB1CACNA1CCYP1A2CYP3A4CYP2D6
Efonidipine SCHEMBL28844127 0.99 ABCB1 (0.97) ABCB1CACNA1CCYP1A2CYP3A4CYP2D6
Efonidipine SCHEMBL27650540 0.98 ABCB1 (0.96) ABCB1CACNA1CCYP1A2CYP3A4CYP2D6
Efonidipine SCHEMBL909287 0.97 ABCB1 (0.95) ABCB1CACNA1CCYP1A2CYP3A4CYP2D6
Efonidipine SCHEMBL909286 0.97 ABCB1 (0.95) ABCB1CACNA1CCYP1A2CYP3A4CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 7210 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4741492-A2 NECROSIS INHIBITOR Linkgevity Limited (GB) 2026-05-13 EP claimed
EP-4255391-B1 LUMINOL FOR USE IN THE TREATMENT OF SEQUELAE OF A SARS-COV-2 INFECTION METRIOPHARM AG (CH) 2026-05-06 EP claimed
EP-4648769-A2 NECROSIS INHIBITOR Linkgevity Limited (GB) 2025-11-19 EP claimed
US-20250345332-A1 APROCITENTAN FOR THE TREATMENT OF HYPERTENSION IDORSIA PHARMACEUTICALS LTD (CH) 2025-11-13 US claimed
EP-4615506-A1 USE OF GSK-3 ACTIVATIOR TO MODULATE PROTEASOME ACTIVITY TO PREVENT AGEING ASSOCIATED CONDITIONS AND DISEASES Sahin, Fikret (TR) 2025-09-17 EP claimed
WO-2025111482-A1 COMPLEXING AGENT SALT FORMULATIONS OF PHARMACEUTICAL COMPOUNDS AT LOW STOICHIOMETRIC RATIOS BEXSON BIOMEDICAL, INC. (US) 2025-05-30 WO claimed
EP-4529461-A1 APROCITENTAN FOR THE TREATMENT OF HYPERTENSION Idorsia Pharmaceuticals Ltd (CH) 2025-04-02 EP claimed
CN-119633109-A Application of efonidipine in preparation of dendritic cell immunoadjuvant 中国人民解放军军事科学院军事医学研究院 2025-03-18 CN claimed
CN-119255805-A Can be used for treating hypertension Alpraxitanum of (C) 爱杜西亚药品有限公司 2025-01-03 CN claimed
WO-2024258363-A1 USE OF GSK-3 ACTIVATIOR TO MODULATE PROTEASOME ACTIVITY TO PREVENT AGEING ASSOCIATED CONDITIONS AND DISEASES SAHIN FIKRET (TR) 2024-12-19 WO claimed
JP-3352095-B2 2002-12-03 JP claimed
WO-2002087556-A2 PROBUCOL MONOESTERS AND THEIR USE TO INCREASE PLASMA HDL CHOLESTEROL LEVELS AND IMPROVE HDL FUNCTIONALITY ATHEROGENICS, INC. (US) 2002-11-07 WO claimed
WO-2002060461-A1 BLOOD BRAIN BARRIER MODULATION USING STRESSED AUTOLOGOUS BLOOD CELLS VASOGEN IRELAND LIMITED (IE) 2002-08-08 WO claimed
CN-1315945-A Nitrate salts of antihypertensive drugs NICOX SA (FR) 2001-10-03 CN claimed
JP-2001517210-A 2001-10-02 JP claimed
EP-1087953-A1 NITRATE SALTS OF ANTIHYPERTENSIVE MEDICINES NICOX S.A. (FR) 2001-04-04 EP claimed
CN-1248162-A Topical pharmaceutical composition containing cholinergic agent or calcium channel blocker MICHAEL ALBERT KAMM (GB) 2000-03-22 CN claimed
EP-0969813-A2 TOPICAL PHARMACEUTICAL COMPOSITION COMPRISING A CHOLINERGIC AGENT OR A CALCIUM CHANNEL BLOCKER Kamm, Michael Albert (GB) 2000-01-12 EP claimed
WO-1999067231-A1 NITRATE SALTS OF ANTIHYPERTENSIVE MEDICINES NICOX S.A. (FR) 1999-12-29 WO claimed
WO-1998036733-A2 TOPICAL PHARMACEUTICAL COMPOSITION COMPRISING A CHOLINERGIC AGENT OR A CALCIUM CHANNEL BLOCKER KAMM MICHAEL ALBERT (GB) 1998-08-27 WO claimed