Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP46A1 | Q9Y6A2 | 2/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.37 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.37 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.36 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | PYGL | P06737 | 1/20 | 0.34 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4964874 | 0.79 | CHRM2 (0.43) | CHRM2CHRM3PDK2GPBAR1CNR2 | |
| SCHEMBL4961973 | 0.79 | CHRM2 (0.49) | CHRM2CHRM3PDK2GPBAR1CNR2 | |
| SCHEMBL4962025 | 0.74 | PDK2 (0.37) | CHRM2CHRM3PDK2GPBAR1CNR2 | |
| SCHEMBL3916812 | 0.72 | PDK2 (0.59) | PDK2GPBAR1CNR2HSD17B1HSD17B2 | |
| SCHEMBL4964791 | 0.69 | CHRM2 (0.78) | CHRM2CHRM3KMT2AMEN1 | |
| SCHEMBL5995052 | 0.69 | ALDH1A1 (0.65) | CHRM2CHRM3HTTKMT2ANPC1 | |
| SCHEMBL6420648 | 0.68 | HTT (0.43) | PDK2CNR2HSD17B1HSD17B2HTT | |
| SCHEMBL24011411 | 0.67 | EPHX1 (0.54) | CYP46A1KMT2ANPC1MEN1RAB9A | |
| Hydrochloric Acid SCHEMBL4000833 | 0.67 | SLC6A2 (0.47) | CHRM2CHRM3CNR2KMT2ACYP3A4 | |
| SCHEMBL4962493 | 0.67 | CNR1 (0.44) | CHRM2CHRM3HSD17B1HSD17B2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773780-A4 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2008-01-09 | — | — | EP | claimed |
| EP-1773780-A2 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | Incyte Corporation (US) | 2007-04-18 | — | — | EP | claimed |
| WO-2006012227-A2 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2006-02-02 | — | — | WO | claimed |