Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 1.00 |
| ▸ | RAB9A | P51151 | 6/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.78 |
| ▸ | MEN1 | O00255 | 6/20 | 0.78 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.78 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.73 |
| ▸ | LMNA | P02545 | 2/20 | 0.72 |
| ▸ | MAPT | P10636 | 1/20 | 0.69 |
| ▸ | LTA4H | P09960 | 1/20 | 0.68 |
| ▸ | DHODH | Q02127 | 1/20 | 0.65 |
| ▸ | CASP3 | P42574 | 1/20 | 0.64 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.64 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.64 |
| ▸ | PGR | P06401 | 1/20 | 0.64 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22192264 | 0.97 | RAB9A (0.94) | NPC1RAB9ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL13393187 | 0.93 | RAB9A (0.86) | NPC1RAB9ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL11879987 | 0.91 | RAB9A (0.84) | NPC1RAB9ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL7296687 | 0.88 | RAB9A (0.78) | NPC1RAB9ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL1747309 | 0.88 | RAB9A (0.78) | NPC1RAB9ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL7322517 | 0.87 | RAB9A (0.77) | NPC1RAB9ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL11492866 | 0.86 | RAB9A (0.75) | NPC1RAB9ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL4628689 | 0.86 | RAB9A (0.75) | NPC1RAB9ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL4666205 | 0.85 | RAB9A (0.74) | NPC1RAB9ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL1746787 | 0.85 | RAB9A (0.72) | NPC1RAB9ASMN1; SMN2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1954670-A2 | NUCLEAR RECEPTOR BINDING AGENTS | GTX Inc. (US) | 2008-08-13 | — | — | EP | disclosed |
| WO-2007062230-A2 | NUCLEAR RECEPTOR BINDING AGENTS | GTX, INC. (US) | 2007-05-31 | — | — | WO | disclosed |
| EP-0138684-B1 | 2-(N-PYRROLIDINO)-3-ISOBUTOXY-N-PHENYL-SUBSTITUTED N-BENZYLPROPYL AMINES, THEIR PREPARATION AND THEIR PHARMACEUTICAL USE | RIOM LABORATOIRES- C.E.R.M. "R.L.-CERM" - (S.A.) (FR) | 1989-04-12 | — | — | EP | disclosed |
| US-4645778-A | TREATMENT OF CARDIOVASCULAR DISORDERS | RIOM LABORATOIRES C.E.R.M. "RL-CERM"S.A. (FR) | 1987-02-24 | — | — | US | disclosed |
| EP-0138684-A2 | 2-(N-pyrrolidino)-3-isobutoxy-N-phenyl-substituted N-benzylpropyl amines, their preparation and their pharmaceutical use | RIOM LABORATOIRES- C.E.R.M. "R.L.-CERM" - (S.A.) (FR) | 1985-04-24 | — | — | EP | disclosed |
| US-4163015-A | ANTIBACTERIAL AGENTS | STERLING DRUG INC. (US) | 1979-07-31 | — | — | US | disclosed |
| US-4138405-A | BACTERICIDES | STERLING DRUG INC. (US) | 1979-02-06 | — | — | US | disclosed |