Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK7 | Q13164 | 14/20 | 0.44 |
| ▸ | ACP1 | P24666 | 4/20 | 0.38 |
| ▸ | NPY1R | P25929 | 1/20 | 0.37 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4962769 | 0.95 | MAPK7 (0.45) | MAPK7 | |
| SCHEMBL5078838 | 0.87 | MAPK7 (0.45) | MAPK7 | |
| SCHEMBL4964123 | 0.86 | MAP2K1 (0.39) | ACP1NPY1RMAP2K1 | |
| SCHEMBL4965011 | 0.82 | MAPK7 (0.52) | MAPK7 | |
| SCHEMBL4964717 | 0.82 | CHEK1 (0.48) | MAPK7 | |
| SCHEMBL4963308 | 0.81 | MAPK7 (0.46) | MAPK7 | |
| SCHEMBL4963499 | 0.81 | MAPK7 (0.52) | MAPK7 | |
| SCHEMBL5075226 | 0.81 | AURKA (0.52) | MAPK7 | |
| SCHEMBL4963785 | 0.81 | MAPK7 (0.55) | MAPK7 | |
| SCHEMBL5604236 | 0.80 | AURKA (0.53) | MAPK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893214-A1 | SYNERGISTIC MODULATION OF FLT3 KINASE USING ALKYLQUINOLINES AND ALKYLQUINAZOLINES | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-03-05 | — | — | EP | disclosed |
| EP-1893598-A1 | ALKYLQUINOLINE AND ALKYLQUINAZOLINE KINASE MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-03-05 | — | — | EP | disclosed |
| WO-2006135629-A1 | SYNERGISTIC MODULATION OF FLT3 KINASE USING ALKYLQUINOLINES AND ALKYLQUINAZOLINES | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-12-21 | — | — | WO | disclosed |
| WO-2006135721-A1 | ALKYLQUINOLINE AND ALKYLQUINAZOLINE KINASE MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-12-21 | — | — | WO | disclosed |