Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 8/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | IDE | P14735 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 2/20 | 0.34 |
| ▸ | NR2E3 | Q9Y5X4 | 2/20 | 0.34 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HLCS | P50747 | 3/20 | 0.33 |
| ▸ | CA12 | O43570 | 3/20 | 0.33 |
| ▸ | CA1 | P00915 | 3/20 | 0.33 |
| ▸ | CA2 | P00918 | 3/20 | 0.33 |
| ▸ | CA9 | Q16790 | 3/20 | 0.33 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19751615 | 0.91 | TDP1 (0.42) | TDP1HPSE | |
| SCHEMBL19751664 | 0.91 | TDP1 (0.39) | TDP1L3MBTL1MEN1ABL1LMNA | |
| SCHEMBL4964050 | 0.91 | TDP1 (0.39) | TDP1L3MBTL1MEN1ABL1LMNA | |
| SCHEMBL4967180 | 0.91 | TDP1 (0.42) | TDP1HPSE | |
| SCHEMBL20634873 | 0.91 | TDP1 (0.42) | TDP1HPSE | |
| SCHEMBL4962038 | 0.90 | TDP1 (0.38) | TDP1L3MBTL1MEN1ABL1LMNA | |
| SCHEMBL19751684 | 0.90 | TDP1 (0.38) | TDP1L3MBTL1MEN1ABL1LMNA | |
| SCHEMBL4962673 | 0.87 | TDP1 (0.44) | TDP1L3MBTL1MEN1ABL1LMNA | |
| SCHEMBL19751725 | 0.87 | TDP1 (0.44) | TDP1L3MBTL1MEN1ABL1LMNA | |
| SCHEMBL10109657 | 0.86 | TDP1 (0.42) | TDP1L3MBTL1MEN1ABL1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11731982-B2 | Biotin derivatives | Life Technologies Corporation | 2023-08-22 | — | — | US | disclosed |
| US-11731982-B2 | Biotin derivatives | Life Technologies Corporation | 2023-08-22 | — | — | US | disclosed |
| US-20190322681-A1 | Biotin Derivatives | LIFE TECHNOLOGIES AS (NO) | 2019-10-24 | — | — | US | disclosed |
| EP-2633062-B1 | BIOTIN DERIVATIVES | LIFE TECHNOLOGIES CORP (US) | 2017-12-27 | — | — | EP | disclosed |
| US-20170174700-A1 | Biotin Derivatives | Life Technologies Corporation | 2017-06-22 | — | — | US | disclosed |
| US-20170174700-A1 | Biotin Derivatives | Life Technologies Corporation | 2017-06-22 | — | — | US | disclosed |
| US-9567346-B2 | Biotin derivatives | Life Technologies Corporation (US) | 2017-02-14 | — | — | US | disclosed |
| US-9567346-B2 | Biotin derivatives | Life Technologies Corporation (US) | 2017-02-14 | — | — | US | disclosed |
| US-20140011255-A1 | Biotin Derivatives | Life Technologies Corporation (US) | 2014-01-09 | — | — | US | disclosed |
| US-20140011255-A1 | Biotin Derivatives | Life Technologies Corporation (US) | 2014-01-09 | — | — | US | disclosed |
| WO-2012058635-A1 | BIOTIN DERIVATIVES | Life Technologies Corporation (US) | 2012-05-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11731982-B2 | Biotin derivatives | BTD, HLCS, BRI3BP | TDP1 4350/4885L3MBTL1 1468/4885MEN1 4227/4885 |
| US-20140011255-A1 | Biotin Derivatives | BTD, HLCS, BRI3BP | TDP1 4350/4885L3MBTL1 1468/4885MEN1 4227/4885 |
| US-20190322681-A1 | Biotin Derivatives | BTD, HLCS, BRI3BP | TDP1 4350/4885L3MBTL1 1468/4885MEN1 4227/4885 |
| US-20170174700-A1 | Biotin Derivatives | BTD, HLCS, BRI3BP | TDP1 4350/4885L3MBTL1 1468/4885MEN1 4227/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.