Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.42 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.41 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL496780 | 0.86 | MAPT (0.60) | MAPTTP53GPR35 | |
| SCHEMBL496743 | 0.74 | KDR (0.48) | MET | |
| SCHEMBL496673 | 0.71 | MAPT (0.61) | MAPTTP53 | |
| SCHEMBL496688 | 0.70 | HSP90AB1 (0.52) | MAPTTP53HSP90AB1MET | |
| SCHEMBL497262 | 0.68 | KDR (0.53) | HSP90AB1MET | |
| SCHEMBL8171724 | 0.62 | XDH (0.69) | GPR35 | |
| SCHEMBL496935 | 0.61 | KDR (0.52) | HSP90AB1 | |
| SCHEMBL496898 | 0.61 | MAPT (0.55) | MAPTTP53GPR35 | |
| SCHEMBL5616597 | 0.61 | XDH (0.58) | MAPTTP53GPR35 | |
| SCHEMBL496572 | 0.61 | MAPT (0.52) | MAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8106047-B2 | (4-Methoxyphenyl)-[3-(4-methoxyphenyl)-[1,2,4]triazolo[3,4-a]phthalazin-6-yl]-amine; phosphodiesterase inhibitors; septic shock or vascular edema; neoangiogenesis or inflammatory disease | NYCOMED GMBH (DE) | 2012-01-31 | — | — | US | claimed |