Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 10/20 | 0.37 |
| ▸ | CA1 | P00915 | 9/20 | 0.37 |
| ▸ | CA9 | Q16790 | 7/20 | 0.37 |
| ▸ | CA5A | P35218 | 4/20 | 0.37 |
| ▸ | CA4 | P22748 | 3/20 | 0.37 |
| ▸ | CA6 | P23280 | 3/20 | 0.37 |
| ▸ | CA12 | O43570 | 3/20 | 0.37 |
| ▸ | CA7 | P43166 | 2/20 | 0.37 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.37 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.37 |
| ▸ | CA3 | P07451 | 1/20 | 0.37 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.37 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30311727 | 0.72 | RECQL (0.40) | MAPTCYP2C9LMNATP53CYP1A2 | |
| SCHEMBL21162132 | 0.67 | MAOB (0.41) | MAPTKDM4EHPGDCYP2C9LMNA | |
| SCHEMBL14652740 | 0.67 | MAOB (0.41) | MAPTKDM4EHPGDCYP2C9LMNA | |
| SCHEMBL15583493 | 0.66 | CYP1A2 (0.38) | MAPTCYP2C9LMNATP53CYP1A2 | |
| SCHEMBL4794296 | 0.64 | LMNA (0.39) | MAPTLMNATP53CYP1A2CYP3A4 | |
| SCHEMBL17518709 | 0.64 | SMN1; SMN2 (0.33) | CA2MAPTLMNATP53CYP1A2 | |
| SCHEMBL28036409 | 0.63 | CYP2C19 (0.42) | CYP2C9LMNACYP1A2CYP3A4KDM1A | |
| SCHEMBL18570252 | 0.63 | RECQL (0.33) | MAPTCYP2C9LMNATP53CYP1A2 | |
| SCHEMBL29155608 | 0.63 | POLB (0.35) | CA4MAPTKDM4ELMNATP53 | |
| SCHEMBL5268971 | 0.63 | EDNRA (0.41) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100364971-C | Pyrrolidin-2-ones as factor Xa inhibitors | GLAXO GROUP LTD (GB) | 2008-01-30 | — | — | CN | claimed |
| EP-1888517-A1 | NOVEL 8-SULFONYLAMINO-3 AMINOSUBSTITUTED CHROMAN OR TETRAHYDRONAPHTALENE DERIVATIVES MODULATING THE 5HT6 RECEPTOR | AstraZeneca AB (SE) | 2008-02-20 | — | — | EP | disclosed |
| CN-100364971-C | Pyrrolidin-2-ones as factor Xa inhibitors | GLAXO GROUP LTD (GB) | 2008-01-30 | — | — | CN | disclosed |
| WO-2006126939-A1 | NOVEL 8-SULFONYLAMINO-3 AMINOSUBSTITUTED CHROMAN OR TETRAHYDRONAPHTALENE DERIVATIVES MODULATING THE 5HT6 RECEPTOR | ASTRAZENECA AB (SE) | 2006-11-30 | — | — | WO | disclosed |
| CN-1620434-A | Pyrrolidine-2-ones as factor Xa inhibitors | GLAXO GROUP LTD (GB) | 2005-05-25 | — | — | CN | disclosed |
| EP-1456172-A1 | PYRROLIDINE-2-ONES AS FACTOR XA INHIBITORS | GLAXO GROUP LIMITED (GB) | 2004-09-15 | — | — | EP | disclosed |
| WO-2003053925-A1 | PYRROLIDINE-2-ONES AS FACTOR XA INHIBITORS | GLAXO GROUP LIMITED (GB) | 2003-07-03 | — | — | WO | disclosed |
| WO-1998004260-A1 | SUBSTITUTED BIPHENYL SULFONAMIDE ENDOTHELIN ANTAGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-02-05 | — | — | WO | disclosed |