Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 11/20 | 0.72 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.68 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | KDM1A | O60341 | 1/20 | 0.45 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2168554 | 0.92 | LTA4H (0.77) | LTA4HKCNH2HRH3TLR9 | |
| SCHEMBL2167724 | 0.87 | LTA4H (0.74) | LTA4HKCNH2HRH3TLR9 | |
| SCHEMBL2168682 | 0.84 | LTA4H (1.00) | LTA4HKCNH2TLR9 | |
| SCHEMBL2167826 | 0.84 | LTA4H (0.80) | LTA4HKCNH2HRH3TLR9 | |
| SCHEMBL2168051 | 0.82 | LTA4H (0.95) | LTA4HKCNH2TLR9 | |
| SCHEMBL2169516 | 0.82 | LTA4H (1.00) | LTA4HKCNH2TLR9 | |
| SCHEMBL2170260 | 0.82 | LTA4H (1.00) | LTA4HKCNH2HRH3TLR9 | |
| SCHEMBL2170316 | 0.81 | LTA4H (1.00) | LTA4HKCNH2TLR9 | |
| SCHEMBL2168424 | 0.81 | LTA4H (1.00) | LTA4HKCNH2TLR9 | |
| SCHEMBL2171372 | 0.81 | LTA4H (0.86) | LTA4HKCNH2HRH3PTGS2TLR9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008100564-A1 | LTA4H MODULATORS AND USES THEROF | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-08-21 | — | — | WO | claimed |