Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 11/20 | 0.63 |
| ▸ | OPRD1 | P41143 | 10/20 | 0.63 |
| ▸ | OPRK1 | P41145 | 9/20 | 0.63 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.52 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.52 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.52 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.52 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.52 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.52 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.52 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.52 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.52 |
| ▸ | PARP10 | Q53GL7 | 5/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | PARP15 | Q460N3 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4966147 | 0.99 | OPRM1 (0.62) | OPRM1OPRD1OPRK1GRIN2DGRIN3B | |
| SCHEMBL4964763 | 0.92 | OPRM1 (0.69) | OPRM1OPRD1OPRK1GRIN2DGRIN3B | |
| SCHEMBL4964300 | 0.80 | OPRM1 (0.53) | OPRM1OPRD1OPRK1GRIN2DGRIN3B | |
| SCHEMBL4963842 | 0.79 | OPRM1 (0.48) | OPRM1OPRD1OPRK1GRIN2DGRIN3B | |
| SCHEMBL4964794 | 0.79 | OPRM1 (0.50) | OPRM1OPRD1OPRK1TAAR1KMT2A | |
| SCHEMBL580098 | 0.78 | OPRM1 (1.00) | OPRM1OPRD1OPRK1GRIN2DGRIN3B | |
| SCHEMBL3692341 | 0.78 | OPRM1 (1.00) | OPRM1OPRD1OPRK1GRIN2DGRIN3B | |
| SCHEMBL14132128 | 0.77 | OPRM1 (0.67) | OPRM1OPRD1OPRK1GRIN2DGRIN3B | |
| SCHEMBL4966818 | 0.75 | NPC1 (0.53) | OPRM1OPRD1OPRK1GRIN2DGRIN3B | |
| Hydrochloric Acid SCHEMBL4964796 | 0.74 | NPC1 (0.52) | OPRM1OPRD1OPRK1GRIN2DGRIN3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1606275-B1 | OPIOID RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2008-08-27 | — | — | EP | claimed |
| US-7396943-B2 | Opioid receptor antagonists | ELI LILLY AND COMPANY (US) | 2008-07-08 | — | — | US | claimed |
| EP-1606275-B1 | OPIOID RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2008-08-27 | — | — | EP | disclosed |
| US-7396943-B2 | Opioid receptor antagonists | ELI LILLY AND COMPANY (US) | 2008-07-08 | — | — | US | disclosed |
| US-7396943-B2 | Opioid receptor antagonists | ELI LILLY AND COMPANY (US) | 2008-07-08 | — | — | US | disclosed |