Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MDH2 | P40926 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.39 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.39 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.39 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.39 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.39 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.39 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4962848 | 0.91 | HTT (0.47) | HTTKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL5242756 | 0.90 | HTT (0.49) | HTTKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL4961058 | 0.87 | HTT (0.40) | HTTKDM4EMAPK1ALDH1A1HPGD | |
| SCHEMBL4963567 | 0.84 | HTT (0.43) | HTTKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL4960348 | 0.82 | HTT (0.40) | HTTKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL4961098 | 0.81 | HTT (0.40) | HTTKDM4EMAPK1ALDH1A1HPGD | |
| SCHEMBL4963341 | 0.81 | HTT (0.46) | HTTKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL4961480 | 0.80 | HTT (0.48) | HTTKDM4EMAPK1ALDH1A1HPGD | |
| SCHEMBL3812183 | 0.78 | HTT (0.52) | HTTKDM4E | |
| SCHEMBL5194886 | 0.78 | HTT (0.45) | HTTKDM4EALDH1A1HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1879904-A1 | 4\" AMINO LINKED MACROLIDES USEFUL FOR THE TREATMENT OF MICROBIAL INFECTIONS | GlaxoSmithKline istrazivacki centar Zagreb d.o.o. (HR) | 2008-01-23 | — | — | EP | disclosed |
| WO-2006120545-A1 | 4' AMINO LINKED MACROLIDES USEFUL FOR THE TREATMENT OF MICROBIAL INFECTIONS | GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O. (HR) | 2006-11-16 | — | — | WO | disclosed |