Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK2 | Q15119 | 1/20 | 0.55 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.55 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.43 |
| ▸ | PGR | P06401 | 7/20 | 0.42 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.41 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.41 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.41 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30539488 | 1.00 | PDK2 (0.55) | PDK2PDK4MAPK14CA9ATAD2 | |
| Hydrochloric Acid SCHEMBL7276702 | 0.98 | PDK2 (0.53) | PDK2PDK4MAPK14CA9ATAD2 | |
| SCHEMBL520415 | 0.85 | PDK2 (0.55) | PDK2PDK4ATAD2PGRPDE3B | |
| Hydrochloric Acid SCHEMBL31507926 | 0.83 | PDK2 (0.53) | PDK2PDK4ATAD2PGRPDE3B | |
| SCHEMBL14211046 | 0.81 | CA9 (0.42) | PDK2PDK4MAPK14CA9HTR6 | |
| SCHEMBL7433946 | 0.78 | PDK2 (0.57) | PDK2PDK4MAPK14CA9ATAD2 | |
| SCHEMBL18413758 | 0.78 | CHEK1 (0.47) | PDK2PDK4CA9PGRPDE3B | |
| SCHEMBL2102219 | 0.78 | PDK2 (0.39) | PDK2PDK4MAPK14CA9MEN1 | |
| SCHEMBL15577573 | 0.78 | PDK2 (0.47) | PDK2PDK4MAPK14ATAD2PGR | |
| SCHEMBL2144278 | 0.77 | PDK2 (0.55) | PDK2PDK4MAPK14ATAD2PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 110 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250320184-A1 | SARM1 MODULATORS, PREPARATIONS, AND USES THEREOF | SIRONAX LTD (KY) | 2025-10-16 | — | — | US | disclosed |
| WO-2025090514-A1 | COVALENT SARM1 INHIBITORS | NURA BIO, INC. (US) | 2025-05-01 | — | — | WO | disclosed |
| US-12054488-B2 | Pyrazolopyrimidine compound and preparation method therefor and use thereof in preparation of anti-cancer drug | SUZHOU RAYMON PHARMACEUTICALS COMPANY, LTD. (CN) | 2024-08-06 | — | — | US | disclosed |
| CN-110950868-B | Pyrazolopyrimidine compound, preparation method thereof and application of pyrazolopyrimidine compound in preparation of anti-cancer drugs | 苏州锐明新药研发有限公司 | 2022-05-13 | — | — | CN | disclosed |
| US-20220106316-A2 | PYRAZOLOPYRIMIDINE COMPOUND AND PREPARATION METHOD THEREFOR AND USE THEREOF IN PREPARATION OF ANTI-CANCER DRUG | SUZHOU RAYMON PHARMACEUTICALS COMPANY, LTD. (CN) | 2022-04-07 | — | — | US | disclosed |
| US-20210340146-A1 | PYRAZOLOPYRIMIDINE COMPOUND AND PREPARATION METHOD THEREFOR AND USE THEREOF IN PREPARATION OF ANTI-CANCER DRUG | SUZHOU RAYMON PHARMACEUTICALS COMPANY LTD (CN) | 2021-11-04 | — | — | US | disclosed |
| US-20210340146-A1 | PYRAZOLOPYRIMIDINE COMPOUND AND PREPARATION METHOD THEREFOR AND USE THEREOF IN PREPARATION OF ANTI-CANCER DRUG | SUZHOU RAYMON PHARMACEUTICALS COMPANY LTD (CN) | 2021-11-04 | — | — | US | disclosed |
| CN-110950868-A | Pyrazolopyrimidine compound, preparation method thereof and application thereof in preparing anti-cancer drugs | 苏州锐明新药研发有限公司 | 2020-04-03 | — | — | CN | disclosed |
| WO-2020063636-A1 | PYRAZOLOPYRIMIDINE COMPOUND AND PREPARATION METHOD AND USE THEREOF IN PREPARATION OF ANTI-CANCER DRUG | 苏州锐明新药研发有限公司 | 2020-04-02 | — | — | WO | disclosed |
| WO-2020063636-A1 | PYRAZOLOPYRIMIDINE COMPOUND AND PREPARATION METHOD AND USE THEREOF IN PREPARATION OF ANTI-CANCER DRUG | 苏州锐明新药研发有限公司 | 2020-04-02 | — | — | WO | disclosed |
| US-4963686-A | INTERMEDIATES FOR INOTROPIC AGENTS | BOEHRINGER MANNHEIM GMBH (DE) | 1990-10-16 | — | — | US | disclosed |
| EP-0216165-B1 | BENZODIPYRROLES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS | Roche Diagnostics GmbH (DE) | 1989-11-23 | — | — | EP | disclosed |
| US-4874756-A | CARDIOVASCULAR DISORDERS | BOEHRINGER MANNHEIM GMBH (DE) | 1989-10-17 | — | — | US | disclosed |
| EP-0327986-A2 | Medicaments containing lactams, substituted lactams and process for their preparation | Roche Diagnostics GmbH (DE) | 1989-08-16 | — | — | EP | disclosed |
| US-4835280-A | Indoline compounds for synthesis of pharmaceutically active pyrrolobenzimidazoles | BOEHRINGER MANNHEIM GMBH (DE) | 1989-05-30 | — | — | US | disclosed |
| US-4810801-A | Pyrrolobenzimidazoles, pharmaceutical compositions containing them, and use of them to treat certain heart and circulatory diseases | BOEHRINGER MANNHEIM GMBH (DE) | 1989-03-07 | — | — | US | disclosed |
| CN-85103724-B | Process for preparing pyrrolobenzimidazoles | 曼海姆伯灵格股份公司 | 1988-07-06 | — | — | CN | disclosed |
| EP-0216165-A1 | Benzodipyrroles, processes for their preparation and pharmaceutical compositions containing these compounds | Roche Diagnostics GmbH (DE) | 1987-04-01 | — | — | EP | disclosed |
| CN-85103724-A | The method for preparing novel pyrrolo-benzoglyoxaline | — | 1986-07-02 | — | — | CN | disclosed |
| EP-0161632-A2 | Pyrrolo-benzimidazoles, process for their preparation, medicaments containing them and intermediates | Roche Diagnostics GmbH (DE) | 1985-11-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250320184-A1 | SARM1 MODULATORS, PREPARATIONS, AND USES THEREOF | SARM1, SMN1; SMN2, ADRM1 | PDK2 3167/4885PDK4 3533/4885MAPK14 2680/4885 |
| US-20220106316-A2 | PYRAZOLOPYRIMIDINE COMPOUND AND PREPARATION METHOD THEREFOR AND USE THEREOF IN PREPARATION OF ANTI-CANCER DRUG | PIK3CA, PIK3CD, PIK3R5 | PDK2 140/4885PDK4 361/4885MAPK14 60/4885 |
| US-20210340146-A1 | PYRAZOLOPYRIMIDINE COMPOUND AND PREPARATION METHOD THEREFOR AND USE THEREOF IN PREPARATION OF ANTI-CANCER DRUG | PIK3CA, PIK3CD, PIK3R5 | PDK2 140/4885PDK4 361/4885MAPK14 60/4885 |
| US-12054488-B2 | Pyrazolopyrimidine compound and preparation method therefor and use thereof in preparation of anti-cancer drug | PIK3CA, PIK3CD, PIK3R5 | PDK2 140/4885PDK4 361/4885MAPK14 60/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.