Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 1/20 | 0.53 |
| ▸ | BACE1 | P56817 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 2/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 4/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.42 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.42 |
| ▸ | ESR1 | P03372 | 2/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.42 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.39 |
| ▸ | DAO | P14920 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4706066 | 0.89 | BACE1 (0.59) | TRPA1BACE1HTTALDH1A1GAA | |
| SCHEMBL1021944 | 0.84 | BACE1 (0.68) | TRPA1BACE1HTTALDH1A1MAPT | |
| SCHEMBL19315966 | 0.83 | BACE1 (0.37) | TRPA1BACE1HTTALDH1A1GAA | |
| SCHEMBL5751090 | 0.83 | BACE1 (0.50) | BACE1HTTALDH1A1HSD17B10ALOX15 | |
| SCHEMBL4455444 | 0.82 | BCL2 (0.50) | TRPA1BACE1GAAMAPTPOLB | |
| SCHEMBL5882568 | 0.81 | GABRA1 (0.61) | TRPA1BACE1HTTALDH1A1GAA | |
| SCHEMBL7836755 | 0.81 | HTT (0.40) | BACE1HTTALDH1A1GAAMAPT | |
| SCHEMBL5164363 | 0.81 | HTT (0.59) | BACE1HTTALDH1A1GAAHPGD | |
| SCHEMBL11414411 | 0.80 | KAT8 (0.56) | BACE1ALDH1A1KDM4EHSD17B10ESR1 | |
| SCHEMBL11413686 | 0.80 | KAT8 (0.56) | BACE1ALDH1A1KDM4EHSD17B10ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1954693-A1 | BETA-SECRETASE MODULATORS AND METHODS OF USE | Amgen Inc. (US) | 2008-08-13 | — | — | EP | disclosed |
| WO-2007062007-A1 | BETA-SECRETASE MODULATORS AND METHODS OF USE | AMGEN INC. (US) | 2007-05-31 | — | — | WO | disclosed |