Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK7 | Q13164 | 4/20 | 0.44 |
| ▸ | EGFR | P00533 | 8/20 | 0.43 |
| ▸ | CSF1R | P07333 | 5/20 | 0.43 |
| ▸ | KDR | P35968 | 4/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | KIF5B | P33176 | 1/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.40 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.39 |
| ▸ | FLT1 | P17948 | 3/20 | 0.39 |
| ▸ | FLT4 | P35916 | 3/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.39 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4969267 | 0.94 | MAPK7 (0.42) | MAPK7EGFRCSF1RKDRRET | |
| Trifluoroacetic Acid SCHEMBL4965758 | 0.71 | IRAK4 (0.57) | EGFRKDREHMT2FGFR1FLT1 | |
| Trifluoroacetic Acid SCHEMBL30264700 | 0.71 | KIT (0.46) | MAPK7EGFRKDRPDE10AFGFR1 | |
| SCHEMBL4965766 | 0.71 | PDE10A (0.55) | PDE10AJAK2JAK1JAK3ENPP1 | |
| Trifluoroacetic Acid SCHEMBL30264814 | 0.68 | PDE10A (0.64) | MAPK7EGFRPDE10A | |
| Trifluoroacetic Acid SCHEMBL4969262 | 0.68 | IRAK4 (0.53) | EGFRKDREHMT2FGFR1FLT1 | |
| SCHEMBL3563598 | 0.67 | MAPK7 (0.54) | MAPK7EGFRKDRFGFR1FLT1 | |
| Trifluoroacetic Acid SCHEMBL4969504 | 0.67 | PDE10A (0.39) | MAPK7EGFRKDRPDE10AEHMT2 | |
| SCHEMBL5037882 | 0.67 | MEN1 (0.40) | — | |
| SCHEMBL27438304 | 0.67 | EGFR (0.58) | EGFRCSF1RKDRRETKIF5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899319-A2 | AMINOQUINOLINE AND AMINOQUINAZOLINE KINASE MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-03-19 | — | — | EP | disclosed |
| EP-1893206-A2 | SYNERGISTIC MODULATION OF FLT3 KINASE USING AMINOQUINOLINE AND AMINOQUINAZOLINE KINASE MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-03-05 | — | — | EP | disclosed |
| WO-2006135649-A2 | AMINOQUINOLINE AND AMINOQUINAZOLINE KINASE MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-12-21 | — | — | WO | disclosed |
| WO-2006135636-A2 | SYNERGISTIC MODULATION OF FLT3 KINASE USING AMINOQUINOLINE AND AMINOQUINAZOLINE KINASE MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-12-21 | — | — | WO | disclosed |