Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TACR1 | P25103 | 9/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 8/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.36 |
| ▸ | GABRD | O14764 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.34 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.34 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.34 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.34 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4355418 | 0.69 | SLC6A2 (0.38) | SLC6A4SLC6A2SLC6A3GABRA1GABRA5 | |
| SCHEMBL994550 | 0.68 | ALDH1A1 (0.39) | MEN1KMT2ASLC6A4SLC6A2SLC6A3 | |
| SCHEMBL23778380 | 0.68 | SLC6A2 (0.45) | CYP2D6TACR1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL22689036 | 0.68 | SLC6A2 (0.42) | MEN1CYP2D6KMT2ASLC6A4SLC6A2 | |
| SCHEMBL4577662 | 0.67 | SLC6A4 (0.46) | MEN1CYP2D6KMT2ATACR1SLC6A4 | |
| SCHEMBL5033623 | 0.67 | ALDH1A1 (0.46) | MEN1KMT2ATACR1SLC6A4SLC6A2 | |
| SCHEMBL5040928 | 0.67 | TACR1 (0.51) | TACR1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL4965769 | 0.67 | MAPK7 (0.44) | — | |
| SCHEMBL5037869 | 0.66 | TACR1 (0.41) | CYP2D6TACR1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL5034052 | 0.66 | SLC6A2 (0.43) | SLC6A4SLC6A2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1622914-A4 | NEW PIPERIDINYLAMINO-THIENO 2,3-D PYRIMIDINE COMPOUNDS | EPIX DELAWARE INC (US) | 2008-03-12 | — | — | EP | disclosed |
| EP-1622914-A2 | NEW PIPERIDINYLAMINO-THIENO 2,3-D PYRIMIDINE COMPOUNDS | Predix Pharmaceuticals Holdings, Inc. (US) | 2006-02-08 | — | — | EP | disclosed |
| WO-2004089312-A2 | NEW PIPERIDINYLAMINO-THIENO[2,3-D] PYRIMIDINE COMPOUNDS | PREDIX PHARMACEUTICALS HOLDINGS, INC. (US) | 2004-10-21 | — | — | WO | disclosed |