Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 6/20 | 0.43 |
| ▸ | S1PR3 | Q99500 | 6/20 | 0.43 |
| ▸ | S1PR2 | O95136 | 4/20 | 0.43 |
| ▸ | S1PR4 | O95977 | 3/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | RORC | P51449 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1855128 | 0.94 | S1PR1 (0.50) | S1PR1S1PR3S1PR2S1PR4KCNH2 | |
| SCHEMBL1854388 | 0.94 | S1PR1 (0.50) | S1PR1S1PR3S1PR2S1PR4KCNH2 | |
| Hydrochloric Acid SCHEMBL1855393 | 0.93 | S1PR1 (0.49) | S1PR1S1PR3S1PR2S1PR4KCNH2 | |
| SCHEMBL5044434 | 0.90 | S1PR1 (0.48) | S1PR1S1PR3S1PR2S1PR4KCNH2 | |
| SCHEMBL17225164 | 0.86 | HSD17B10 (0.49) | HDAC1HDAC8TAAR1ALDH1A1FFAR1 | |
| SCHEMBL5045143 | 0.86 | PTGES (0.45) | S1PR1S1PR3S1PR2S1PR4SCN8A | |
| SCHEMBL4966334 | 0.85 | S1PR1 (0.57) | S1PR1S1PR3S1PR2S1PR4HDAC1 | |
| SCHEMBL5045624 | 0.84 | S1PR1 (0.56) | S1PR1S1PR3S1PR2S1PR4HDAC1 | |
| SCHEMBL4964614 | 0.84 | S1PR1 (0.56) | S1PR1S1PR3S1PR2S1PR4HDAC1 | |
| SCHEMBL5048891 | 0.83 | FFAR1 (0.41) | HDAC1HDAC8TAAR1FFAR1PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732534-B1 | USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS | SERONO LAB (CH) | 2008-07-23 | — | — | EP | claimed |
| EP-1904048-A1 | GLEPP-1 INHIBITORS IN THE TREATMENT OF AUTOIMMUNE AND/OR INFLAMMATORY DISORDERS | LABORATOIRES SERONO S.A. (CH) | 2008-04-02 | — | — | EP | disclosed |
| WO-2007009959-A1 | GLEPP-1 INHIBITORS IN THE TREATMENT OF AUTOIMMUNE AND/OR INFLAMMATORY DISORDERS | LABORATOIRES SERONO S.A. (CH) | 2007-01-25 | — | — | WO | disclosed |
| EP-1732534-A1 | USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS | Applied Research Systems ARS Holding N.V. (AN) | 2006-12-20 | — | — | EP | disclosed |
| WO-2005082347-A1 | USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS | APLLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2005-09-09 | — | — | WO | disclosed |