Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | PLK1 | P53350 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 2/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.36 |
| ▸ | TACR2 | P21452 | 2/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SHBG | P04278 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5044440 | 0.91 | TAAR1 (0.40) | TAAR1FFAR1PTGDR2MIF | |
| SCHEMBL17225164 | 0.89 | HSD17B10 (0.49) | HSD17B10TSHRFAAHPLK1HDAC1 | |
| SCHEMBL5044254 | 0.85 | FFAR1 (0.47) | HSD17B10TSHRFFAR1PTGDR2MMP2 | |
| SCHEMBL5043877 | 0.81 | MAOB (0.43) | ALDH1A1LMNACYP3A4 | |
| SCHEMBL5039909 | 0.80 | HSD17B10 (0.44) | HSD17B10TSHRFAAHPLK1HDAC1 | |
| SCHEMBL1855128 | 0.80 | S1PR1 (0.50) | HSD17B10TSHRFAAHPLK1HDAC1 | |
| SCHEMBL5044821 | 0.80 | HSD17B10 (0.44) | HSD17B10TSHRFAAHPLK1HDAC1 | |
| SCHEMBL1854388 | 0.80 | S1PR1 (0.50) | HSD17B10TSHRFAAHPLK1HDAC1 | |
| SCHEMBL5047560 | 0.80 | TAAR1 (0.46) | TAAR1CA2FDFT1MIF | |
| SCHEMBL2089930 | 0.80 | TAAR1 (0.55) | HSD17B10FAAHPLK1HDAC1HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904048-A1 | GLEPP-1 INHIBITORS IN THE TREATMENT OF AUTOIMMUNE AND/OR INFLAMMATORY DISORDERS | LABORATOIRES SERONO S.A. (CH) | 2008-04-02 | — | — | EP | disclosed |
| WO-2007009959-A1 | GLEPP-1 INHIBITORS IN THE TREATMENT OF AUTOIMMUNE AND/OR INFLAMMATORY DISORDERS | LABORATOIRES SERONO S.A. (CH) | 2007-01-25 | — | — | WO | disclosed |