Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 2/20 | 0.41 |
| ▸ | DAO | P14920 | 5/20 | 0.41 |
| ▸ | MIF | P14174 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 2/20 | 0.37 |
| ▸ | FDFT1 | P37268 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5044440 | 0.90 | TAAR1 (0.40) | TAAR1MAOBDAOMIF | |
| SCHEMBL1696674 | 0.84 | TAAR1 (0.61) | TAAR1MAOBDAOMIFIDO1 | |
| SCHEMBL5043877 | 0.82 | MAOB (0.43) | MAOBMEN1KMT2A | |
| Ammonia Solution, Strong SCHEMBL6193177 | 0.82 | TAAR1 (0.59) | TAAR1MAOBDAOMIFIDO1 | |
| SCHEMBL8990753 | 0.80 | MAOB (0.61) | TAAR1MAOBDAOMIFFDFT1 | |
| SCHEMBL4965849 | 0.80 | HSD17B10 (0.43) | TAAR1MIFFDFT1CA2 | |
| SCHEMBL9809579 | 0.78 | MAOB (0.63) | TAAR1MAOBDAOMIFIDO1 | |
| SCHEMBL934227 | 0.75 | TAAR1 (0.73) | TAAR1MAOBDAOMIFIDO1 | |
| SCHEMBL27346303 | 0.74 | TAAR1 (0.45) | TAAR1MAOBDAOMIFIDO1 | |
| SCHEMBL9185806 | 0.74 | TAAR1 (0.50) | TAAR1MAOBDAOMIFIDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732534-B1 | USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS | SERONO LAB (CH) | 2008-07-23 | — | — | EP | claimed |
| EP-1732534-A1 | USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS | Applied Research Systems ARS Holding N.V. (AN) | 2006-12-20 | — | — | EP | claimed |
| WO-2005082347-A1 | USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS | APLLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2005-09-09 | — | — | WO | claimed |