Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 5/20 | 0.61 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.61 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | KDM1A | O60341 | 5/20 | 0.45 |
| ▸ | MAOA | P21397 | 3/20 | 0.45 |
| ▸ | CTPS1 | P17812 | 5/20 | 0.45 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.43 |
| ▸ | EDNRB | P24530 | 1/20 | 0.42 |
| ▸ | EDNRA | P25101 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4966276 | 0.92 | HSD11B1 (0.63) | HSD11B1HSD17B1HSD17B2MEN1POLB | |
| SCHEMBL4965066 | 0.90 | HSD11B1 (0.64) | HSD11B1HSD17B1HSD17B2MEN1POLB | |
| SCHEMBL4967377 | 0.89 | HSD11B1 (0.63) | HSD11B1HSD17B1HSD17B2MEN1POLB | |
| SCHEMBL4966321 | 0.89 | HSD11B1 (0.58) | HSD11B1HSD17B1HSD17B2MEN1POLB | |
| SCHEMBL4962519 | 0.88 | HSD11B1 (0.57) | HSD11B1HSD17B1HSD17B2MEN1POLB | |
| SCHEMBL4963955 | 0.87 | HSD11B1 (0.56) | HSD11B1HSD17B1HSD17B2MEN1POLB | |
| SCHEMBL4963074 | 0.87 | HSD11B1 (0.56) | HSD11B1HSD17B1HSD17B2MEN1POLB | |
| SCHEMBL4963930 | 0.87 | HSD11B1 (0.60) | HSD11B1HSD17B1HSD17B2MEN1POLB | |
| SCHEMBL4965872 | 0.86 | HSD11B1 (0.60) | HSD11B1HSD17B1HSD17B2MEN1POLB | |
| SCHEMBL4963065 | 0.86 | HSD11B1 (0.58) | HSD11B1HSD17B1HSD17B2MEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888544-A2 | HYDROXYSTEROID DEHYDROGENASE INHIBITORS | Takeda San Diego, Inc. (US) | 2008-02-20 | — | — | EP | claimed |
| WO-2006066109-A2 | HYDROXYSTEROID DEHYDROGENASE INHIBITORS | TAKEDA SAN DIEGO, INC. (US) | 2006-06-22 | — | — | WO | claimed |
| EP-1888544-A2 | HYDROXYSTEROID DEHYDROGENASE INHIBITORS | Takeda San Diego, Inc. (US) | 2008-02-20 | — | — | EP | disclosed |
| WO-2006066109-A2 | HYDROXYSTEROID DEHYDROGENASE INHIBITORS | TAKEDA SAN DIEGO, INC. (US) | 2006-06-22 | — | — | WO | disclosed |