Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.46 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 8/20 | 0.43 |
| ▸ | DRD2 | P14416 | 8/20 | 0.43 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1509568 | 0.90 | ABCG2 (0.44) | ABCG2ABCB1HDAC6HTR1ADRD2 | |
| SCHEMBL16462882 | 0.83 | ABCG2 (0.51) | ABCG2ABCB1HDAC6CARM1ATM | |
| SCHEMBL1509498 | 0.83 | ABCG2 (0.48) | ABCG2ABCB1HDAC6CARM1CHEK1 | |
| SCHEMBL14090388 | 0.81 | ABCG2 (0.47) | ABCG2ABCB1CARM1MAPTSMN1; SMN2 | |
| SCHEMBL14090595 | 0.81 | TBK1 (0.47) | ABCB1HDAC6MAPTSMN1; SMN2MEN1 | |
| SCHEMBL14090449 | 0.78 | ABCG2 (0.44) | ABCG2ABCB1DRD2CARM1HPSE | |
| SCHEMBL14090446 | 0.78 | HSD17B10 (0.45) | ABCB1HDAC6MAPTSMN1; SMN2HPGD | |
| SCHEMBL14090604 | 0.78 | CDK4 (0.50) | HTR1ACARM1MAPTHTR2ALMNA | |
| SCHEMBL14090422 | 0.78 | ABCG2 (0.51) | ABCG2ABCB1HPSE | |
| SCHEMBL14090421 | 0.78 | ABCB1 (0.46) | ABCG2ABCB1CARM1HPSE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080207635-A1 | Heterocyclic compounds useful in the treatment of neoplastic diseases, inflammatory disorders and immunomodulatory disorders | CHEMBRIDGE CORPORATION | 2008-08-28 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080207635-A1 | Heterocyclic compounds useful in the treatment of neoplastic diseases, inflammatory disorders and immunomodulatory disorders | LCK, MALT1, MYD88 | ABCG2 3134/4885ABCB1 2579/4885HDAC6 541/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.