Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRIM33 | Q9UPN9 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 2/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.38 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4967834 | 0.83 | MEN1 (0.45) | TRIM33MEN1CYP1A2KMT2AKEAP1 | |
| SCHEMBL20596074 | 0.80 | SSTR4 (0.44) | TRIM33MEN1CYP1A2KMT2AKEAP1 | |
| SCHEMBL376307 | 0.79 | DYRK1A (0.49) | TRIM33MEN1CYP1A2KMT2AKEAP1 | |
| SCHEMBL359745 | 0.75 | TRIM33 (0.55) | TRIM33MEN1CYP1A2KMT2AMAOB | |
| SCHEMBL16686943 | 0.75 | PIK3CG (0.45) | — | |
| SCHEMBL20899915 | 0.75 | S1PR3 (0.42) | TRIM33MEN1CYP1A2KMT2AKEAP1 | |
| SCHEMBL20899964 | 0.74 | MAOB (0.50) | TRIM33MEN1CYP1A2KMT2AMAOB | |
| SCHEMBL30832524 | 0.72 | KEAP1 (0.46) | TRIM33MEN1CYP1A2KMT2AKEAP1 | |
| SCHEMBL30832522 | 0.72 | KEAP1 (0.46) | TRIM33MEN1CYP1A2KMT2AKEAP1 | |
| SCHEMBL10204904 | 0.71 | DYRK1A (0.45) | TRIM33MEN1CYP1A2KMT2AKEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778685-B1 | INDOLIZINE CARBOXAMIDES AND THE AZA AND DIAZA DERIVATIVES THEREOF | SANOL ARZNEI SCHWARZ GMBH (DE) | 2008-03-26 | — | — | EP | disclosed |