Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 2/20 | 0.74 |
| ▸ | QRFPR | Q96P65 | 1/20 | 0.74 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | TP53 | P04637 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | WDR5 | P61964 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | MYC | P01106 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4505443 | 1.00 | HTR6 (0.74) | HTR6QRFPRADRA1AALDH1A1TP53 | |
| SCHEMBL4962886 | 0.87 | HTR6 (0.57) | HTR6QRFPRADRA1AALDH1A1TP53 | |
| SCHEMBL4512908 | 0.87 | HTR6 (0.57) | HTR6QRFPRADRA1AALDH1A1TP53 | |
| SCHEMBL4515515 | 0.86 | HTR6 (0.73) | HTR6QRFPRALDH1A1TP53LMNA | |
| SCHEMBL4958896 | 0.86 | HTR6 (0.56) | HTR6QRFPRADRA1ATP53NPSR1 | |
| SCHEMBL4516618 | 0.86 | HTR6 (0.56) | HTR6QRFPRADRA1ATP53NPSR1 | |
| SCHEMBL4529672 | 0.85 | HTR6 (1.00) | HTR6QRFPRALDH1A1TP53LMNA | |
| SCHEMBL4521081 | 0.85 | HTR6 (1.00) | HTR6QRFPRALDH1A1TP53LMNA | |
| SCHEMBL4961410 | 0.85 | HTR6 (1.00) | HTR6QRFPRALDH1A1TP53LMNA | |
| SCHEMBL4518573 | 0.84 | HTR6 (0.69) | HTR6QRFPRALDH1A1TP53LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888518-A1 | NOVEL 8-SULFONYL-3 AMINOSUBSTITUTED CHROMAN OR TETRAHYDRONAPHTALENE DERIVATIVES MODULATING THE 5HT6 RECEPTOR | AstraZeneca AB (SE) | 2008-02-20 | — | — | EP | disclosed |
| WO-2006126938-A1 | NOVEL 8-SULFONYL-3 AMINOSUBSTITUTED CHROMAN OR TETRAHYDRONAPHTALENE DERIVATIVES MODULATING THE 5HT6 RECEPTOR | ASTRAZENECA AB (SE) | 2006-11-30 | — | — | WO | disclosed |