Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dicloralurea. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dicloralurea SCHEMBL134347 | 0.81 | HPGD (0.45) | HPGD | |
| Dicloralurea SCHEMBL6534881 | 0.76 | HPGD (0.41) | HPGD | |
| Dicloralurea SCHEMBL2674558 | 0.74 | HPGD (0.41) | HPGD | |
| Dicloralurea SCHEMBL3965395 | 0.74 | HPGD (0.40) | HPGD | |
| Dicloralurea SCHEMBL5418303 | 0.73 | HPGD (0.39) | HPGD | |
| Mecloralurea SCHEMBL547686 | 0.73 | HPGD (0.44) | HPGD | |
| Dicloralurea SCHEMBL17968228 | 0.72 | HPGD (0.41) | HPGD | |
| Dicloralurea SCHEMBL4075855 | 0.71 | HPGD (0.40) | HPGD | |
| Dicloralurea SCHEMBL5099542 | 0.70 | EPHX1 (0.40) | HPGD | |
| Dicloralurea SCHEMBL6289122 | 0.69 | HPGD (0.36) | HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1954259-A2 | AMIDINE DERIVATIVES FOR IN VIVO IMAGING | Hammersmith Imanet, Ltd (GB) | 2008-08-13 | — | — | EP | disclosed |
| WO-2007063286-A2 | AMIDINE DERIVATIVES FOR IN VIVO IMAGING | HAMMERSMITH IMANET LIMITED (GB) | 2007-06-07 | — | — | WO | disclosed |